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一种多距离和多波长扩散相关光谱系统的开发与特性研究

Development and characterization of a multidistance and multiwavelength diffuse correlation spectroscopy system.

作者信息

Tamborini Davide, Farzam Parisa, Zimmermann Bernhard, Wu Kuan-Cheng, Boas David A, Franceschini Maria Angela

机构信息

Harvard Medical School, MGH/HST Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, United States.

Boston University, Boston University Neurophotonics Center, Boston, Massachusetts, United States.

出版信息

Neurophotonics. 2018 Jan;5(1):011015. doi: 10.1117/1.NPh.5.1.011015. Epub 2017 Sep 21.

Abstract

This paper presents a multidistance and multiwavelength diffuse correlation spectroscopy (DCS) approach and its implementation to simultaneously measure the optical proprieties of deep tissue as well as the blood flow. The system consists of three long coherence length lasers at different wavelengths in the near-infrared, eight single-photon detectors, and a correlator board. With this approach, we collect both light intensity and DCS data at multiple distances and multiple wavelengths, which provide unique information to fit for all the parameters of interest: scattering, blood flow, and hemoglobin concentration. We present the characterization of the system and its validation with phantom measurements.

摘要

本文提出了一种多距离和多波长漫射相关光谱法(DCS)及其实现方法,用于同时测量深部组织的光学特性以及血流情况。该系统由三个近红外波段不同波长的长相干长度激光器、八个单光子探测器和一个相关器板组成。通过这种方法,我们在多个距离和多个波长下收集光强和DCS数据,这些数据提供了独特的信息,以拟合所有感兴趣的参数:散射、血流和血红蛋白浓度。我们展示了该系统的特性及其通过体模测量的验证。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ff3/5607257/a5ebc12a7312/NPh-005-011015-g001.jpg

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