Doronin Alexander, Yakovlev Vladislav V, Bagnato Vanderlei S
School of Engineering and Computer Science, Victoria University of Wellington, Wellington, 6140, New Zealand.
Department of Physics and Astronomy, Texas A&M University, College Station, Texas, USA.
Biomed Opt Express. 2024 Feb 15;15(3):1682-1693. doi: 10.1364/BOE.515962. eCollection 2024 Mar 1.
In this report, we propose a novel strategy for the photodynamic approach to the treatment of melanoma, aiming to mitigate the excessive absorption and consequent thermal effects. The cornerstone of this approach is an innovative structured illumination technique that optimizes light delivery to the tissue. The methodology of this study involves the development of an optical model of human skin with the presence of melanoma and an accurate simulation technique of photon transport within the complex turbid scattering medium. To assess the effectiveness of our proposed strategy, we introduced a cost function reflecting the irradiated volume and optical radiation absorption within the target area/volume occupied by malformation. By utilizing the cost function, we refine the offset illumination parameters for a variety of target system parameters, ensuring increased efficiency of photodynamic therapy. Our computer simulation results introduce a promising new path towards improved photodynamic melanoma treatments, potentially leading to better therapeutic outcomes and reduced side effects. Further experimental validation is needed to confirm these theoretical advancements, which could contribute towards revolutionizing current melanoma photodynamic treatment methodologies.
在本报告中，我们提出了一种用于光动力治疗黑色素瘤的新策略，旨在减轻过度吸收及随之产生的热效应。该方法的核心是一种创新的结构化照明技术，可优化光向组织的传输。本研究的方法包括建立含黑色素瘤的人体皮肤光学模型，以及在复杂浑浊散射介质中进行光子传输的精确模拟技术。为评估我们提出的策略的有效性，我们引入了一个成本函数，该函数反映了畸形所占据的目标区域/体积内的照射体积和光辐射吸收。通过利用该成本函数，我们针对各种目标系统参数优化了偏移照明参数，确保提高光动力疗法的效率。我们的计算机模拟结果为改进光动力黑色素瘤治疗引入了一条有前景的新途径，有望带来更好的治疗效果并减少副作用。需要进一步的实验验证来证实这些理论进展，这可能有助于彻底改变当前的黑色素瘤光动力治疗方法。
