使用分形调节来描绘认知弹性：来自拉什记忆与衰老项目的横断面和纵向证据。
Delineating cognitive resilience using fractal regulation: Cross-sectional and longitudinal evidence from the Rush Memory and Aging Project.
机构信息
Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Medical Biodynamics Program, Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
出版信息
Alzheimers Dement. 2024 May;20(5):3203-3210. doi: 10.1002/alz.13747. Epub 2024 Mar 18.
INTRODUCTION
Degradation of fractal patterns in actigraphy independently predicts dementia risk. Such observations motivated the study to understand the role of fractal regulation in the context of neuropathologies.
METHODS
We examined associations of fractal regulation with neuropathologies and longitudinal cognitive changes in 533 older participants who were followed annually with actigraphy and cognitive assessments until death with brain autopsy performed. Two measures for fractal patterns were extracted from actigraphy, namely, α (representing the fractal regulation at time scales of <90 min) and α (for time scales 2 to 10 h).
RESULTS
We found that larger α was associated with lower burdens of Lewy body disease or cerebrovascular disease pathologies; both α and α were associated with cognitive decline. They explained an additional significant portion of the variance in the rate of cognitive decline above and beyond neuropathologies.
DISCUSSION
Fractal patterns may be used as a biomarker for cognitive resilience against dementia-related neuropathologies.
简介
活动记录仪中分形图案的退化独立预测痴呆风险。这些观察结果促使我们研究分形调节在神经病理学背景下的作用。
方法
我们研究了分形调节与神经病理学以及 533 名年龄较大的参与者的纵向认知变化之间的关联，这些参与者每年都通过活动记录仪和认知评估进行随访，直到进行脑尸检。从活动记录仪中提取了两种分形模式的指标，即 α（代表 <90 分钟时间尺度上的分形调节）和 α（代表 2 至 10 小时的时间尺度）。
结果
我们发现，较大的 α 与路易体病或脑血管病病理负担较低有关；α 和 α 均与认知能力下降有关。它们在神经病理学之外，还可以解释认知能力下降速度的额外显著变化部分。
讨论
分形模式可用作对抗与痴呆相关的神经病理学的认知弹性的生物标志物。
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