衰老储备和恢复力的概念框架。
A framework for concepts of reserve and resilience in aging.
机构信息
Cognitive Neuroscience Division, Department of Neurology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Departments of Psychiatry and Neurology, John Hopkins University, Baltimore, MD, USA.
出版信息
Neurobiol Aging. 2023 Apr;124:100-103. doi: 10.1016/j.neurobiolaging.2022.10.015. Epub 2022 Dec 19.
The study of factors, across species, that allow some individuals to age more successfully than others has important implications for individual wellbeing as well as health education, policy and intervention. Design of studies and communication across investigators in this area has been hampered by a diversity of terminology. The Collaboratory on Research Definitions for Reserve and Resilience in Cognitive Aging and Dementia was funded by the National Institute on Aging and established in 2019 as a 3-year process of developing consensus definitions and research guidelines. The proposed Framework is based on an iterative process including 3 annual Workshops, focused workgroups, and input from numerous international investigators. It suggests the overarching term: resilience, and presents operational definitions for 3 concepts: cognitive reserve, brain maintenance, and brain reserve. Twelve pilot studies that integrate these definitions are presented. The use of a common vocabulary and operational definitions will facilitate even greater progress in understanding the factors that are associated with successful aging.
跨物种研究导致某些个体比其他个体更成功衰老的因素，对个体的健康和幸福感以及健康教育、政策和干预都有重要意义。由于术语的多样性，该领域的研究设计和研究人员之间的交流受到了阻碍。认知衰老和痴呆储备和恢复力研究定义协作组由美国国家老龄化研究所资助，成立于 2019 年，为期 3 年，旨在制定共识定义和研究指南。该框架基于一个迭代过程，包括 3 次年度研讨会、重点工作组以及来自众多国际研究人员的投入。它提出了一个总体术语：韧性，并提出了 3 个概念的操作性定义：认知储备、大脑维护和大脑储备。提出了 12 项整合这些定义的试点研究。使用通用词汇和操作性定义将有助于在理解与成功衰老相关的因素方面取得更大的进展。
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