Department of Endocrine and Metabolic, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Jiangxi Clinical Research Center for Endocrine and Metabolic Disease, Jiangxi Branch of National Clinical Research Center for Metabolic Disease, Nanchang, Jiangxi, China.
Queen Mary School, The Nanchang University, Nanchang, Jiangxi, China.
CNS Neurosci Ther. 2024 Mar;30(3):e14579. doi: 10.1111/cns.14579.
This study aimed to investigate the resting-state functional connectivity and topologic characteristics of brain networks in patients with diabetic optic neuropathy (DON).
Resting-state functional magnetic resonance imaging scans were performed on 23 patients and 41 healthy control (HC) subjects. We used independent component analysis and graph theoretical analysis to determine the topologic characteristics of the brain and as well as functional network connectivity (FNC) and topologic properties of brain networks.
Compared with HCs, patients with DON showed altered global characteristics. At the nodal level, the DON group had fewer nodal degrees in the thalamus and insula, and a greater number in the right rolandic operculum, right postcentral gyrus, and right superior temporal gyrus. In the internetwork comparison, DON patients showed significantly increased FNC between the left frontoparietal network (FPN-L) and ventral attention network (VAN). Additionally, in the intranetwork comparison, connectivity between the left medial superior frontal gyrus (MSFG) of the default network (DMN) and left putamen of auditory network was decreased in the DON group.
DON patients altered node properties and connectivity in the DMN, auditory network, FPN-L, and VAN. These results provide evidence of the involvement of specific brain networks in the pathophysiology of DON.
本研究旨在探讨糖尿病性视神经病变（DON）患者静息态功能连接和脑网络拓扑特征。
对 23 例患者和 41 名健康对照（HC）受试者进行静息态功能磁共振成像扫描。我们使用独立成分分析和图论分析来确定脑的拓扑特征以及功能网络连接（FNC）和脑网络的拓扑性质。
与 HC 相比，DON 患者表现出全局特征的改变。在节点水平上，DON 组丘脑和脑岛的节点度减少，右侧 Rolandic 脑回、右侧中央后回和右侧颞上回的节点度增加。在网络间比较中，DON 患者左额顶网络（FPN-L）与腹侧注意网络（VAN）之间的 FNC 显著增加。此外，在网络内比较中，DON 组默认网络（DMN）的左侧额上回（MSFG）与听觉网络的左侧豆状核之间的连接减少。
DON 患者的 DMN、听觉网络、FPN-L 和 VAN 中节点特性和连接发生改变。这些结果为特定脑网络参与 DON 病理生理学提供了证据。
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