Chen Si-Yi, Cai Guo-Qian, Liang Rong-Bin, Yang Qi-Cheng, Min You-Lan, Ge Qian-Min, Li Biao, Shi Wen-Qing, Li Qiu-Yu, Zeng Xian-Jun, Shao Yi
Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang, China.
Department of Radiology, the First Affiliated Hospital of Nanchang University, Nanchang, China.
Quant Imaging Med Surg. 2021 May;11(5):2125-2137. doi: 10.21037/qims-20-453.
To evaluate functional connection density (FCD) in patients with diabetic optic neuropathy (DON) using the resting functional connectivity (FC) method, and to determine the abnormal areas of brain activity.
Patients with DON (n=22; 10 male, 12 female) and healthy controls (HCs; n=22; 10 male, 12 female) were included in the study. The basic characteristics of the groups were matched. Functional magnetic resonance imaging (fMRI) was conducted with participants at rest, and long- and short-range FCD (long FCD and IFCD, respectively) were measured. Receiver operating characteristic (ROC) curve analysis was also conducted to determine whether DON and HC participants could be distinguished using fMRI indicators.
Compared with HCs, the long FCD values of the left lingual gyrus, right lingual gyrus, right fusiform gyrus, and medial and lateral cingulate gyri were decreased in patients with DON. Further, the IFCD values of the left superior temporal gyrus, left inferior temporal gyrus, right inferior temporal gyrus, left cerebellar area 8, and right cerebellar Crus2 area were higher in patients with DON than in the HCs.
DON is associated with abnormal spontaneous brain activity. Our findings contribute to elucidating the mechanisms underlying the neuropathology of DON, and provide direction for further clinical research.
采用静息态功能连接（FC）方法评估糖尿病性视神经病变（DON）患者的功能连接密度（FCD），并确定大脑活动的异常区域。
本研究纳入了DON患者（n = 22；男性10例，女性12例）和健康对照者（HCs；n = 22；男性10例，女性12例）。两组的基本特征相匹配。对参与者进行静息态功能磁共振成像（fMRI），并测量长程和短程FCD（分别为长FCD和iFCD）。还进行了受试者工作特征（ROC）曲线分析，以确定是否可以使用fMRI指标区分DON患者和HC参与者。
与HCs相比，DON患者左侧舌回、右侧舌回、右侧梭状回以及内侧和外侧扣带回的长FCD值降低。此外，DON患者左侧颞上回、左侧颞下回、右侧颞下回、左侧小脑8区和右侧小脑 Crus2区的iFCD值高于HCs。
DON与大脑自发活动异常有关。我们的研究结果有助于阐明DON神经病理学的潜在机制，并为进一步的临床研究提供方向。
