Department of Gastroenterology, The Second Clinical Medical College of Lanzhou University, Lanzhou University Second Hospital, Lanzhou, China.
Institute of Sensor Technology, Gansu Academy of Sciences, Key Laboratory of Sensor and Sensing Technology of Gansu, Lanzhou, China.
Helicobacter. 2024 Mar-Apr;29(2):e13068. doi: 10.1111/hel.13068.
Helicobacter pylori (H. pylori) is a pathogenic microorganism that colonizes the human gastric mucosa and can lead to various gastric disorders, including gastritis, gastric ulcers, and gastric cancer. However, the increasing prevalence of antibiotic resistance in H. pylori has prompted the search for alternative treatment options. Photodynamic therapy has emerged as a potential alternative therapy, thus offering the advantage of avoiding some of the side effects associated with antibiotics and effectively targeting drug-resistant strains. In the postantibiotic era, photodynamic therapy (PDT) has shown promise as a novel treatment for H. pylori infection. This review focused on elucidating the mechanism of photodynamic therapy in the treatment of H. pylori. Additionally, we present an overview of the current research on photodynamic therapy by examining both standalone photodynamic therapy and combination therapies for H. pylori infection treatment. Furthermore, the safety profile of photodynamic therapy was also evaluated. Finally, we discuss the challenges and prospects associated with this innovative technology, with an aim to provide new insights and methodologies for the treatment of H. pylori infection.
幽门螺杆菌（H. pylori）是一种定植于人类胃黏膜的致病微生物，可导致多种胃部疾病，包括胃炎、胃溃疡和胃癌。然而，H. pylori 对抗生素的耐药性日益增加，促使人们寻找替代治疗方法。光动力疗法已成为一种潜在的替代疗法，因此具有避免与抗生素相关的一些副作用和有效靶向耐药菌株的优势。在后抗生素时代，光动力疗法（PDT）已显示出作为治疗 H. pylori 感染的一种新方法的潜力。本综述重点阐述了光动力疗法治疗 H. pylori 的作用机制。此外，我们通过检查光动力疗法单独治疗和联合治疗 H. pylori 感染的研究，对光动力疗法的当前研究进行了概述。此外，还评估了光动力疗法的安全性概况。最后，我们讨论了与这项创新技术相关的挑战和前景，旨在为 H. pylori 感染的治疗提供新的见解和方法。
