Department of Women's and Children's Health, Salesi Hospital, 60123 Ancona, Italy.
Center of Epidemiology, Biostatistics and Medical Information Technology, Università Politecnica delle Marche, 60020 Ancona, Italy.
Diabetes Res Clin Pract. 2024 Apr;210:111621. doi: 10.1016/j.diabres.2024.111621. Epub 2024 Mar 16.
To analyze metabolic outcomes, diabetes impact and device satisfaction in children and adolescents with type 1 diabetes in Italy who used different treatment modalities for diabetes care in a real-life context.
In this multicenter, nationwide, cross-sectional study, 1464 participants were enrolled at a routine visit. The following treatment modalities were considered MDI + SMBG; MDI + CGM; Sensor Augmented Pump Therapy; predictive management of low glucose; Hybrid Closed Loop (HCL); Advanced Hybrid Closed Loop (AHCL). Health related quality of life was evaluated by the Italian version of the Diabetes Impact and Device Satisfaction Scale (DIDS) questionnaire.
Patients treated with AID systems were more likely to have HbA1c ≤ 6.5 %, higher percentage of time with glucose levels between 70 and 180 mg/dL, lower percentage of time with glucose levels above 180 mg/dL, higher device satisfaction, and reduced impact of diabetes. All the therapeutic modalities with respect to MDI + CGM, except for MDI + SMBG, contributed to increase the device satisfaction. HCL and AHCL respect to MDI + CGM were associated with lower diabetes impact.
Real-life use of automated insulin delivery systems is associated with reduced type 1 diabetes impact, increased device satisfaction, and achievement of glycemic goals.
在意大利，分析不同治疗方案下儿童和青少年 1 型糖尿病患者的代谢结果、糖尿病影响和设备满意度。
本多中心、全国性、横断面研究纳入了 1464 名在常规就诊时的参与者。考虑了以下治疗方案：MDI+SMBG；MDI+CGM；传感器增强型泵治疗；低血糖预测管理；混合闭环（HCL）；高级混合闭环（AHCL）。使用意大利版糖尿病影响和设备满意度量表（DIDS）问卷评估健康相关生活质量。
使用 AID 系统的患者更有可能达到 HbA1c≤6.5%，葡萄糖水平在 70 至 180mg/dL 之间的时间百分比更高，葡萄糖水平高于 180mg/dL 的时间百分比更低，设备满意度更高，糖尿病影响降低。与 MDI+CGM 相比，除了 MDI+SMBG 之外，所有治疗方案都有助于提高设备满意度。与 MDI+CGM 相比，HCL 和 AHCL 与较低的糖尿病影响相关。
自动化胰岛素输送系统的实际应用与降低 1 型糖尿病影响、提高设备满意度和实现血糖目标有关。
