阿尔茨海默病患者大脑中固有免疫反应向适应性免疫反应的转变与tau蛋白病进展相关。
Switch of innate to adaptative immune responses in the brain of patients with Alzheimer's disease correlates with tauopathy progression.
作者信息
Costa Marcos R
机构信息
Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE facteurs de risqué et déterminants moléculaires des maladies liées au vieillissement, DISTALZ, 1 rue du Professeur Calmette, 59019, Lille, France.
Brain Institute, Federal University of Rio Grande do Norte, Natal, Brazil.
出版信息
NPJ Aging. 2024 Mar 18;10(1):19. doi: 10.1038/s41514-024-00145-5.
Neuroinflammation is a key feature of Alzheimer's disease (AD). In this work, analysis of single- cell RNA-sequencing (scRNA-seq) data obtained from the brain of patients with AD provides evidence supporting a switch from an innate to an adaptative immune response during tauopathy progression, with both disease-associated microglia (DAM) and CD8+ T cells becoming more frequent at advanced Braak stages.
神经炎症是阿尔茨海默病（AD）的一个关键特征。在这项研究中，对从AD患者大脑中获取的单细胞RNA测序（scRNA-seq）数据的分析提供了证据，支持在tau蛋白病进展过程中从先天性免疫反应向适应性免疫反应的转变，在Braak晚期阶段，疾病相关小胶质细胞（DAM）和CD8 + T细胞均变得更加常见。
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