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基于 FSI 模拟和基于 MR 弹性成像的脑硬度评估非侵入性颅内顺应性的可行性。

Feasibility of assessing non-invasive intracranial compliance using FSI simulation-based and MR elastography-based brain stiffness.

机构信息

Department of Neurological Surgery, The University of Chicago, 5841 S. Maryland Ave, Chicago, IL, 60637, USA.

出版信息

Sci Rep. 2024 Mar 18;14(1):6493. doi: 10.1038/s41598-024-57250-4.

DOI:10.1038/s41598-024-57250-4
PMID:38499758
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10948846/
Abstract

Intracranial compliance (ICC) refers to the change in intracranial volume per unit change in intracranial pressure (ICP). Magnetic resonance elastography (MRE) quantifies brain stiffness by measuring the shear modulus. Our objective is to investigate the relationship between ICC and brain stiffness through fluid-structure interaction (FSI) simulation, and to explore the feasibility of using MRE to assess ICC based on brain stiffness. This is invaluable due to the clinical importance of ICC, as well as the fast and non-invasive nature of the MRE procedure. We employed FSI simulation in hydrocephalus patients with aqueductal stenosis to non-invasively calculate ICP which is the basis of the calculation of ICC and FSI-based brain stiffness. The FSI simulated parameters used have been validated with experimental data. Our results showed that there is no relationship between FSI simulated-based brain stiffness and ICC in hydrocephalus patients. However, MRE-based brain stiffness may be sensitive to changes in intracranial fluid dynamic parameters such as cerebral perfusion pressure (CPP), cerebral blood flow (CBF), and ICP, as well as to mechano-vascular changes in the brain, which are determining parameters in ICC assessment. Although optimism has been found regarding the assessment of ICC using MRE-based brain stiffness, especially for acute-onset brain disorders, further studies are necessary to clarify their direct relationship.

摘要

颅内顺应性（ICC）是指颅内压力（ICP）每单位变化时颅内容积的变化。磁共振弹性成像（MRE）通过测量剪切模量来量化脑硬度。我们的目标是通过流体-结构相互作用（FSI）模拟研究 ICC 和脑硬度之间的关系，并探讨基于脑硬度使用 MRE 评估 ICC 的可行性。这是非常有价值的，因为 ICC 的临床重要性以及 MRE 程序的快速和非侵入性。我们在患有导水管狭窄的脑积水患者中使用 FSI 模拟来无创地计算 ICP，这是 ICC 计算和基于 FSI 的脑硬度计算的基础。用于 FSI 模拟的参数已经过实验数据验证。我们的结果表明，在脑积水患者中，FSI 模拟的脑硬度与 ICC 之间没有关系。然而，MRE 基于脑硬度可能对颅内流体动力学参数（如脑灌注压（CPP）、脑血流量（CBF）和 ICP）的变化以及 ICC 评估中的脑机械血管变化敏感。虽然在使用 MRE 基于脑硬度评估 ICC 方面发现了乐观的情况，特别是对于急性发作的脑部疾病，但仍需要进一步的研究来澄清它们之间的直接关系。

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本文引用的文献

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Can magnetic resonance elastography serve as a diagnostic tool for gradual-onset brain disorders?磁共振弹性成像能否作为渐进性脑部疾病的诊断工具？
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Why Intracranial Compliance Is Not Utilized as a Common Practical Tool in Clinical Practice.为何颅内顺应性未被用作临床实践中的常用实用工具。
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