Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Magn Reson Med. 2018 Feb;79(2):1043-1051. doi: 10.1002/mrm.26738. Epub 2017 May 9.
The homeostasis of intracranial pressure (ICP) is of paramount importance for maintaining normal brain function. A noninvasive technique capable of making direct measurements of ICP currently does not exist. MR elastography (MRE) is capable of noninvasively measuring brain tissue stiffness in vivo, and may act as a surrogate to measure ICP. The objective of this study was to investigate the impact of changing ICP on brain stiffness using MRE in a swine model.
Baseline MRE measurements were obtained, and then catheters were surgically placed into the left and right lateral ventricles of three animals. ICP was systematically increased over the range of 0 to 55 millimeters mercury (mmHg), and stiffness measurements were made using brain MRE at vibration frequencies of 60 hertz (Hz), 90 Hz, 120 Hz, and 150 Hz.
A significant linear correlation between stiffness and ICP in the cross-subject comparison was observed for all tested vibrational frequencies (P ≤ 0.01). The 120 Hz (0.030 ± 0.004 kilopascal (kPa)/mmHg, P < 0.0001) and 150 Hz (0.031 ± 0.008 kPa/mmHg, P = 0.01) vibrational frequencies had nearly identical slopes, which were approximately two- to three-fold higher than the 90 Hz (0.017 ± 0.002 kPa/mmHg, P < 0.0001) and 60 Hz (0.009 ± 0.002 kPa/mmHg, P = 0.001) slopes, respectively.
In this study, MRE demonstrated the potential for noninvasive measurement of changes in ICP. Magn Reson Med 79:1043-1051, 2018. © 2017 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
颅内压 (ICP) 的内稳性对于维持正常脑功能至关重要。目前还没有一种能够直接测量 ICP 的非侵入性技术。磁共振弹性成像 (MRE) 能够无创地活体测量脑组织的硬度，并可能作为一种替代方法来测量 ICP。本研究的目的是在猪模型中通过 MRE 研究 ICP 变化对脑硬度的影响。
获得基线 MRE 测量值，然后将导管手术放置在三只动物的左、右侧脑室中。将 ICP 系统地升高至 0 至 55 毫米汞柱 (mmHg) 的范围内，并使用脑 MRE 在 60 赫兹 (Hz)、90 Hz、120 Hz 和 150 Hz 的振动频率下进行硬度测量。
在跨受试者比较中，所有测试的振动频率均观察到硬度与 ICP 之间存在显著的线性相关性 (P≤0.01)。120 Hz(0.030±0.004 千帕斯卡 (kPa)/mmHg，P<0.0001)和 150 Hz(0.031±0.008 kPa/mmHg，P=0.01)振动频率的斜率几乎相同，约为 90 Hz(0.017±0.002 kPa/mmHg，P<0.0001)和 60 Hz(0.009±0.002 kPa/mmHg，P=0.001)斜率的两到三倍。
在这项研究中，MRE 显示出了无创测量 ICP 变化的潜力。磁共振医学 79:1043-1051,2018。©2017 作者 磁共振医学由 Wiley 期刊出版公司代表国际磁共振医学学会出版。这是根据知识共享署名-非商业性-禁止演绎 4.0 国际许可协议授予的许可。在遵守许可的情况下，您可以在任何媒体中不受限制地使用、分发和复制该作品，前提是您正确引用原始作品。
