Department of Neurological Surgery, University of Chicago, Chicago, IL, USA.
Commun Biol. 2022 Nov 8;5(1):1198. doi: 10.1038/s42003-022-04128-8.
The unpredictable complexities in hydrocephalus shunt outcomes may be related to the recovery behavior of brain tissue after shunting. The simulated cerebrospinal fluid (CSF) velocity and intracranial pressure (ICP) over 15 months after shunting were validated by experimental data. The mean strain and creep of the brain had notable changes after shunting and their trends were monotonic. The highest stiffness of the hydrocephalic brain was in the first consolidation phase (between pre-shunting to 1 month after shunting). The viscous component overcame and damped the input load in the third consolidation phase (after the fifteenth month) and changes in brain volume were stopped. The long-intracranial elastance (long-IE) changed oscillatory after shunting and there was not a linear relationship between long-IE and ICP. We showed the long-term effect of the viscous component on brain recovery behavior of hydrocephalic brain. The results shed light on the brain recovery mechanism after shunting and the mechanisms for shunt failure.
分流术后脑积水结果的不可预测的复杂性可能与分流术后脑组织的恢复行为有关。通过实验数据验证了分流术后 15 个月的模拟脑脊髓液（CSF）速度和颅内压（ICP）。分流术后脑的平均应变和蠕变有显著变化，且其趋势是单调的。脑积水脑的最高刚性在第一个固结阶段（分流前到分流后 1 个月之间）。粘性分量在第三个固结阶段（第 15 个月后）克服并阻尼输入负载，并且脑体积的变化停止。分流术后，长颅内弹性（long-IE）呈振荡变化，并且 long-IE 与 ICP 之间没有线性关系。我们展示了粘性分量对脑积水脑恢复行为的长期影响。结果揭示了分流术后脑恢复机制和分流失败机制。
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