Key Laboratory of the Second Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China.
Department of Neurology, Second Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China.
Neurol Sci. 2024 Aug;45(8):3809-3815. doi: 10.1007/s10072-024-07467-y. Epub 2024 Mar 19.
Parkinson's disease (PD) is viewed as a progressively deteriorating neurodegenerative disorder, the exact etiology of which remains not fully deciphered to this date. The gut microbiota could play a crucial role in PD development by modulating the human immune system.
This study aims to explore the relationship between gut microbiota and PD, focusing on how immune characteristics may both directly and indirectly influence their interaction.
Utilizing cumulative data from genome-wide association studies (GWAS), our research conducted a two-sample Mendelian randomization (MR) analysis to clarify the association between the gut microbiome and PD. Additionally, by employing a two-step MR approach, we assessed the impact of gut microbiota on PD development via immune characteristics and quantified HLA-DR mediation effect on plasmacytoid dendritic cells (pDCs).
We discovered significant associations between PD and microbiota, comprising one class, one order, two families, and two genera. Furthermore, we explored the extent to which HLA-DR on pDCs mediates the effect of Butyrivibrio gut microbiota on PD.
Our study emphasizes the complex interactions between the gut microbiota, immune characteristics, and PD. The relationships and intermediary roles identified in our research provide important insights for developing potential therapies that target the gut microbiome to alleviate symptoms in PD patients.
帕金森病（PD）被视为一种进行性恶化的神经退行性疾病，其确切病因至今仍未完全阐明。肠道微生物群可能通过调节人体免疫系统在 PD 的发展中起关键作用。
本研究旨在探讨肠道微生物群与 PD 之间的关系，重点研究免疫特征如何直接和间接影响它们的相互作用。
利用全基因组关联研究（GWAS）的累积数据，我们进行了两样本孟德尔随机化（MR）分析，以阐明肠道微生物群与 PD 之间的关联。此外，我们还采用两步 MR 方法，通过免疫特征评估肠道微生物群对 PD 发展的影响，并量化 HLA-DR 对浆细胞样树突状细胞（pDC）的中介效应。
我们发现 PD 与微生物群之间存在显著关联，包括一个类、一个目、两个科和两个属。此外，我们探讨了 HLA-DR 在 pDC 上对肠道微生物群对 PD 影响的中介作用程度。
本研究强调了肠道微生物群、免疫特征和 PD 之间的复杂相互作用。我们研究中确定的关系和中介作用为开发针对肠道微生物群的潜在治疗方法以减轻 PD 患者的症状提供了重要的见解。
