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研究与临床实践中的脑刺激技术:帕金森病应用及治疗潜力的全面综述

Brain Stimulation Techniques in Research and Clinical Practice: A Comprehensive Review of Applications and Therapeutic Potential in Parkinson's Disease.

作者信息

Moshayedi Ata Jahangir, Mokhtari Tahmineh, Emadi Andani Mehran

机构信息

School of Information Engineering, Jiangxi University of Science and Technology, Ganzhou 341000, China.

Department of Entomology and Nematology, UCD Comprehensive Cancer Center, University of California, Davis, CA 95616, USA.

出版信息

Brain Sci. 2024 Dec 27;15(1):20. doi: 10.3390/brainsci15010020.


DOI:10.3390/brainsci15010020
PMID:39851388
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11763832/
Abstract

Parkinson's Disease (PD) is a progressive neurodegenerative disorder characterized by a range of motor and non-motor symptoms (NMSs) that significantly impact patients' quality of life. This review aims to synthesize the current literature on the application of brain stimulation techniques, including non-invasive methods such as transcranial magnetic stimulation (TMS), transcranial electrical stimulation (tES), transcranial focused ultrasound stimulation (tFUS), and transcutaneous vagus nerve stimulation (tVNS), as well as invasive approaches like deep brain stimulation (DBS). We explore the efficacy and safety profiles of these techniques in alleviating both motor impairments, such as bradykinesia and rigidity, and non-motor symptoms, including cognitive decline, depression, and impulse control disorders. Current findings indicate that while non-invasive techniques present a favorable safety profile and are effective for milder symptoms, invasive methods like DBS provide significant relief for severe cases that are unresponsive to other treatments. Future research is needed to optimize stimulation parameters, establish robust clinical protocols, and expand the application of these technologies across various stages of PD. This review underscores the potential of brain stimulation as a vital therapeutic tool in managing PD, paving the way for enhanced treatment strategies and improved patient outcomes.

摘要

帕金森病(PD)是一种进行性神经退行性疾病,其特征是一系列运动和非运动症状(NMSs),这些症状会显著影响患者的生活质量。本综述旨在综合当前关于脑刺激技术应用的文献,包括非侵入性方法,如经颅磁刺激(TMS)、经颅电刺激(tES)、经颅聚焦超声刺激(tFUS)和经皮迷走神经刺激(tVNS),以及侵入性方法,如深部脑刺激(DBS)。我们探讨了这些技术在减轻运动障碍(如运动迟缓、僵硬)和非运动症状(包括认知衰退、抑郁和冲动控制障碍)方面的疗效和安全性。目前的研究结果表明,虽然非侵入性技术具有良好的安全性,对较轻症状有效,但像DBS这样的侵入性方法能为对其他治疗无反应的严重病例提供显著缓解。未来需要开展研究以优化刺激参数、建立完善的临床方案,并扩大这些技术在帕金森病各个阶段的应用。本综述强调了脑刺激作为治疗帕金森病的重要治疗工具的潜力,为改进治疗策略和改善患者预后铺平了道路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3da5/11763832/06ad81162dc2/brainsci-15-00020-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3da5/11763832/4f4a095cc09b/brainsci-15-00020-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3da5/11763832/f9949b22e4ca/brainsci-15-00020-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3da5/11763832/06ad81162dc2/brainsci-15-00020-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3da5/11763832/4f4a095cc09b/brainsci-15-00020-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3da5/11763832/f9949b22e4ca/brainsci-15-00020-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3da5/11763832/06ad81162dc2/brainsci-15-00020-g003.jpg

相似文献

[1]
Brain Stimulation Techniques in Research and Clinical Practice: A Comprehensive Review of Applications and Therapeutic Potential in Parkinson's Disease.

Brain Sci. 2024-12-27

[2]
A Computational Model of Deep Brain Stimulation for Parkinson's Disease Tremor and Bradykinesia.

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[3]
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Neuroimage Clin. 2015-3-24

[4]
Neuromodulation Approaches in Parkinson's Disease Using Deep Brain Stimulation and Transcranial Magnetic Stimulation.

J Geriatr Psychiatry Neurol. 2021-7

[5]
The Effects of Non-Invasive Brain Stimulation on Quantitative EEG in Patients With Parkinson's Disease: A Systematic Scoping Review.

Front Neurol. 2022-3-2

[6]
Clinical neurophysiology in the treatment of movement disorders: IFCN handbook chapter.

Clin Neurophysiol. 2024-8

[7]
Cortical Plasticity Induction by Pairing Subthalamic Nucleus Deep-Brain Stimulation and Primary Motor Cortical Transcranial Magnetic Stimulation in Parkinson's Disease.

J Neurosci. 2016-1-13

[8]
Non-invasive brain stimulation for Parkinson's disease: Current concepts and outlook 2015.

NeuroRehabilitation. 2015

[9]
Impulse control and related behavioral disorders in Parkinson's disease. Risk factors, diagnosis, and management. Is there a possible role for non-invasive brain stimulation?

Neurol Sci. 2025-4-7

[10]
Novel Non-invasive Transcranial Electrical Stimulation for Parkinson's Disease.

Front Aging Neurosci. 2022-4-12

引用本文的文献

[1]
Challenges and lessons learned in attempts to develop in vitro models for ultrasound neuromodulation using local field potential measurements in hippocampal tissue.

Biophys J. 2025-6-30

本文引用的文献

[1]
Transcranial direct current stimulation for Parkinson's disease: systematic review and meta-analysis of motor and cognitive effects.

NPJ Parkinsons Dis. 2024-11-6

[2]
Invasive neurophysiological recordings in human basal ganglia. What have we learned about non-motor behaviour?

Eur J Neurosci. 2024-11

[3]
Towards multimodal cognition-based treatment for cognitive impairment in Parkinson's disease: drugs, exercise, non-invasive brain stimulation and technologies.

Curr Opin Neurol. 2024-12-1

[4]
Long-Term Dementia Risk in Parkinson Disease.

Neurology. 2024-9-10

[5]
A retrospective study of Parkinson's disease in Southwest China 2021-2024: An age-based approach.

Exp Gerontol. 2024-10-1

[6]
The Role of Non-Invasive Brain Modulation in Identifying Disease Biomarkers for Diagnostic and Therapeutic Purposes in Parkinsonism.

Brain Sci. 2024-7-12

[7]
New Perspectives of Deep Brain Stimulation Indications for Parkinson's Disease: A Critical Review.

Brain Sci. 2024-6-26

[8]
Non-Invasive Brain Sensing Technologies for Modulation of Neurological Disorders.

Biosensors (Basel). 2024-7-9

[9]
A Comprehensive Approach to Parkinson's Disease: Addressing Its Molecular, Clinical, and Therapeutic Aspects.

Int J Mol Sci. 2024-6-29

[10]
Objective sleep enhancement in Parkinson's disease: A sham-controlled trial of low-frequency repetitive transcranial magnetic stimulation over the right dorsolateral prefrontal cortex.

Parkinsonism Relat Disord. 2024-9

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