Tangestani Hadith, Jamshidi Ali, Yari Zahra, Jalaliyan Zahrasadat, Ghalandari Hamid, Hekmatdoost Azita, Rashvand Samaneh, Mohammadi Baghmolae Amirhossein, Emamat Hadi
Department of Nutrition, Bushehr University of Medical Sciences, Bushehr, Iran.
The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran.
Heliyon. 2024 Mar 6;10(6):e27556. doi: 10.1016/j.heliyon.2024.e27556. eCollection 2024 Mar 30.
BACKGROUND & AIMS: Ulcerative colitis (UC) is a recurrent, inflammatory, autoimmune intestinal disease. The dietary calcium to phosphorus (Ca:P) ratio is suggested to affect the inividuals' normal metabolic and inflammatory pathways. The present study aimed to investigate the association between dietary Ca:P ratio and the odds of developing UC in a case-control format.
The study included sixty-two currently diagnosed UC patients and one hundred twenty-four matched controls, designed as a case-control study. The dietary intakes of the participants were assessed by a food frequency questionnaire (FFQ), and the dietary Ca:P ratio was calculated. The association between tertiles of Ca:P ratio and UC was examined using the logistic regression. P-values <0.05 were considered as significant.
The study sample consisted of participants with an average age of 36.63 ± 12.42 years and a mean body mass index (BMI) of 25.39 ± 3.82 kg/m. The overall energy-adjusted ratio of Ca:P was 0.74 ± 0.11. In the multivariate model, after adjustment for potential confounders, participants in the third tertile of dietary Ca:P ratio had a lower odds of developing UC compared to the lowest tertlie (OR: 0.34, 95% CI: 0.13-0.87; p = 0.026).
Our results indicate that a higher ratio of dietary Ca:P ratio might be protective against developing UC. However, further studies are warranted to examine this association in various populations.
溃疡性结肠炎（UC）是一种复发性炎症性自身免疫性肠道疾病。饮食中钙磷（Ca:P）比值被认为会影响个体的正常代谢和炎症途径。本研究旨在采用病例对照研究形式，探讨饮食中Ca:P比值与患UC几率之间的关联。
该研究纳入了62例目前确诊的UC患者和124例匹配的对照，设计为病例对照研究。通过食物频率问卷（FFQ）评估参与者的饮食摄入量，并计算饮食中Ca:P比值。使用逻辑回归分析Ca:P比值三分位数与UC之间的关联。P值<0.05被认为具有统计学意义。
研究样本包括平均年龄为36.63±12.42岁、平均体重指数（BMI）为25.39±3.82kg/m²的参与者。总体能量调整后的Ca:P比值为0.74±0.11。在多变量模型中，在调整潜在混杂因素后，饮食中Ca:P比值处于第三三分位数的参与者患UC的几率低于最低三分位数者（比值比：0.34，95%置信区间：0.13 - 0.87；p = 0.026）。
我们的结果表明，较高的饮食Ca:P比值可能对预防UC有保护作用。然而，需要进一步研究在不同人群中检验这种关联。
