Khademi Zeinab, Saneei Parvane, Hassanzadeh-Keshteli Ammar, Daghaghzadeh Hamed, Tavakkoli Hamid, Adibi Peyman, Esmaillzadeh Ahmad
Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Front Nutr. 2021 Feb 10;7:602090. doi: 10.3389/fnut.2020.602090. eCollection 2020.
Despite the inflammatory nature of inflammatory bowel disease (IBD), limited data are available on the association of inflammatory potential of the diet and risk of ulcerative colitis (UC). We aimed to investigate the association of inflammatory potential of the diet (IPD) score and odds of UC in a case-control study. Patients with UC were enrolled from Iranian IBD registry, whose disease was confirmed by a gastroenterologist. Controls were selected randomly from the Study of the Epidemiology of Psycho Alimentary Health and Nutrition (SEPAHAN) study, a large population-based study on more than 8,000 apparently healthy individuals. Dietary intakes of 28 food items obtained from a validated dish-based food frequency questionnaire (FFQ), were used to compute IPD score. This case-control study was carried out among 109 cases and 218 randomly chosen controls. Mean age of cases and controls was 39.5 ± 10.0 and 41.5 ± 11.8 y, respectively. Totally, 52% of study participants were female and 48% were male. After controlling for age, sex, and body mass index (BMI), we found that the patients with UC were more likely to be in the highest quartile of IPD score compared with controls (OR: 2.83; 95% CI: 1.41-5.69, -trend < 0.001). This association strengthened after additional adjustment for education, smoking, medical history, and physical activity (OR: 3.48; 95% CI: 1.32-9.10, -trend = 0.003). When we took dietary habits into account, the association was slightly attenuated (OR: 3.33; 95% CI: 1.20-9.20, -trend = 0.005). We found that adherence to a pro-inflammatory diet was positively associated with greater odds of UC. Further studies are required to confirm these findings.
尽管炎症性肠病（IBD）具有炎症性质，但关于饮食的炎症潜力与溃疡性结肠炎（UC）风险之间关联的数据有限。我们旨在通过一项病例对照研究来调查饮食炎症潜力（IPD）评分与UC几率之间的关联。UC患者从伊朗IBD登记处招募，其疾病由胃肠病学家确诊。对照组从精神营养健康与营养流行病学研究（SEPAHAN）中随机选取，该研究是一项针对8000多名明显健康个体的大型人群研究。从经过验证的基于菜肴的食物频率问卷（FFQ）中获取的28种食物的饮食摄入量，用于计算IPD评分。这项病例对照研究在109例病例和218名随机选择的对照中进行。病例组和对照组的平均年龄分别为39.5±10.0岁和41.5±11.8岁。总体而言，52%的研究参与者为女性，48%为男性。在控制了年龄、性别和体重指数（BMI）后，我们发现与对照组相比，UC患者更有可能处于IPD评分的最高四分位数（OR：2.83；95%CI：1.41 - 5.69，趋势<0.001）。在对教育程度、吸烟、病史和身体活动进行额外调整后，这种关联得到加强（OR：3.48；95%CI：1.32 - 9.10，趋势 = 0.003）。当我们考虑饮食习惯时，这种关联略有减弱（OR：3.33；95%CI：1.20 - 9.20，趋势 = 0.005）。我们发现坚持促炎饮食与更高的UC几率呈正相关。需要进一步研究来证实这些发现。
