Sadeghi Omid, Khademi Zeinab, Saneei Parvane, Hassanzadeh-Keshteli Ammar, Daghaghzadeh Hamed, Tavakkoli Hamid, Adibi Peyman, Esmaillzadeh Ahmad
Nutrition and Food Security Research Center, Department of Community Nutrition, Student Research Committee, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Crohns Colitis 360. 2024 Feb 21;6(1):otae009. doi: 10.1093/crocol/otae009. eCollection 2024 Jan.
Ulcerative colitis (UC) causes long-lasting inflammation and ulcers in the gut. Limited observational data are available linking dietary magnesium intake and UC. In the present study, we aimed to investigate the association between dietary magnesium intake and UC in adults.
The current population-based case-control study was performed on 109 UC patients and 218 age (±2 years) and sex-matched controls. The diagnosis of UC was made according to the standard criteria by a gastroenterology specialist. Dietary intakes were assessed using a validated self-administrated 106-item dish-based Food Frequency Questionnaire (FFQ). We also used a pretested questionnaire to collect data on potential confounders.
Individuals in the top tertile of magnesium intake were less likely to have UC compared with those in the bottom tertile. A significant inverse relationship was found between dietary magnesium intake and UC (odds ratio [OR]: 0.32, 95% confidence interval [CI]: 0.18-0.59) in the crude model. This relationship was also observed when we took several potential confounding into account (OR: 0.30, 95% CI: 0.14-0.68).
Adherence to a magnesium-rich diet may have a role in preventing UC. However, further studies are needed to confirm our findings.
溃疡性结肠炎（UC）会导致肠道长期炎症和溃疡。关于饮食中镁摄入量与UC之间关联的观察数据有限。在本研究中，我们旨在调查成年人饮食中镁摄入量与UC之间的关联。
当前基于人群的病例对照研究对109例UC患者和218名年龄（±2岁）及性别匹配的对照进行。UC的诊断由胃肠病学专家根据标准标准做出。饮食摄入量使用经过验证的基于106项菜品的自填式食物频率问卷（FFQ）进行评估。我们还使用了经过预测试的问卷来收集潜在混杂因素的数据。
与镁摄入量最低三分位数的个体相比，镁摄入量最高三分位数的个体患UC的可能性较小。在粗模型中，饮食中镁摄入量与UC之间存在显著的负相关关系（优势比[OR]：0.32，95%置信区间[CI]：0.18 - 0.59）。当我们考虑几个潜在混杂因素时，这种关系也得到了观察（OR：0.30，95% CI：0.14 - 0.68）。
坚持富含镁的饮食可能在预防UC中发挥作用。然而，需要进一步研究来证实我们的发现。
