Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.
Department of Biomedical Science, Seoul National University College of Medicine, Seoul, Korea.
J Korean Med Sci. 2024 Mar 18;39(10):e85. doi: 10.3346/jkms.2024.39.e85.
Female infertility is a crucial problem with significant implications for individuals and society. In this study, we explore risk factors for infertility in Korean women.
A total of 986 female patients who visited six major infertility clinics in Korea were recruited from April to December 2014. Fertile age-matched controls were selected from two nationwide survey study participants. Conditional logistic regression after age-matching was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) of each risk factor for infertility.
Women with a body mass index (BMI) < 18.5 kg/m² had 1.35 times higher odds of infertility (OR, 1.35; 95% CI, 1.03-1.77), while those with a BMI ≥ 25.0 kg/m² had even higher odds (OR, 2.06; 95% CI, 1.61-2.64) compared to women with a normal BMI (18.5 kg/m² ≤ BMI < 25 kg/m²). Ever-smokers exhibited 4.94 times higher odds of infertility compared to never-smokers (95% CI, 3.45-8.85). Concerning alcohol consumption, women who consumed ≥ 7 glasses at a time showed 3.13 times significantly higher odds of infertility than those who consumed ≤ 4 glasses at a time (95% CI, 1.79-5.48). Lastly, women with thyroid disease demonstrated 1.44 times higher odds of infertility compared to women without thyroid disease (95% CI, 1.00-2.08).
Female infertility in Korea was associated with underweight, obesity, smoking, alcohol consumption, and thyroid disease.
女性不孕是一个具有重要意义的问题，对个人和社会都有重大影响。本研究旨在探讨韩国女性不孕的相关危险因素。
本研究共纳入了 2014 年 4 月至 12 月期间在韩国六家主要不孕诊所就诊的 986 名女性患者，并从两项全国性调查研究参与者中选取了年龄匹配的生育能力正常的对照组。采用条件 logistic 回归分析，对每个不孕相关危险因素进行比值比（OR）及其 95%置信区间（CI）的估计。
与 BMI（体重指数）为 18.5kg/m² 的正常体重女性相比，BMI<18.5kg/m²的女性不孕风险增加 1.35 倍（OR，1.35；95%CI，1.03-1.77），而 BMI≥25.0kg/m²的女性不孕风险更高（OR，2.06；95%CI，1.61-2.64）。与从不吸烟的女性相比，有吸烟史的女性不孕风险增加 4.94 倍（95%CI，3.45-8.85）。就饮酒而言，与每次饮酒≤4 杯的女性相比，每次饮酒≥7 杯的女性不孕风险显著增加 3.13 倍（95%CI，1.79-5.48）。此外，患有甲状腺疾病的女性不孕风险是无甲状腺疾病女性的 1.44 倍（95%CI，1.00-2.08）。
韩国女性不孕与体重过轻、肥胖、吸烟、饮酒和甲状腺疾病有关。
