Lei Xiong, Liu Xiling, Yu Chunchun, Xia Lijing, Zhou Liwen, Yao Can, Xu Zhixiao
Department of Emergency, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Front Nutr. 2024 Dec 4;11:1484756. doi: 10.3389/fnut.2024.1484756. eCollection 2024.
An imbalance of the pro-oxidant and antioxidant profiles in the body contributes to the development of diseases, including female infertility.
In this study, we performed a secondary analysis of the National Health and Nutrition Examination Survey and calculated the values of oxidative balance score (OBS). A weighted logistic regression model was used to explore the potential relationship between OBS (continuous factor and quartile set) and female infertility, and the P for trend was calculated. Subgroup analyses were also carried out further to explore the association between OBS and female infertility, and the P for interactions were obtained.
There were 1,626 females (aged 18 to 45) included in the study, including 198 with infertility and a prevalence of approximately 13.28%. Multifactorial logistic regression showed a 5% decrease in infertility for each unit increased in OBS (OR, 0.95; 95% CI, 0.92 to 0.98). When OBS was used as a categorical variable, female infertility decreased by 60% in the highest OBS group compared with the lowest OBS group (OR, 0.40; 95% CI, 0.21 to 0.74). In addition, subgroup analyses showed that the negative association between OBS and infertility was significant in the non-chronic disease (hypertension and diabetes) population, those with less than a high school educational background, poverty-to-income ratio (1 to 3), and those with more than 30 years of age.
Higher OBS was negatively associated with female infertility. Further prospective studies are needed to determine causality and to provide new perspectives on female infertility in the context of diet and lifestyle.
体内促氧化剂和抗氧化剂水平失衡会导致包括女性不孕症在内的多种疾病的发生。
在本研究中，我们对美国国家健康与营养检查调查进行了二次分析，并计算了氧化平衡评分（OBS）值。采用加权逻辑回归模型探讨OBS（连续因素和四分位数组）与女性不孕症之间的潜在关系，并计算趋势P值。还进一步进行了亚组分析，以探讨OBS与女性不孕症之间的关联，并获得交互作用的P值。
该研究纳入了1626名年龄在18至45岁之间的女性，其中198名患有不孕症，患病率约为13.28%。多因素逻辑回归显示，OBS每增加一个单位，不孕症发生率降低5%（比值比[OR]，0.95；95%置信区间[CI]，0.92至0.98）。当将OBS作为分类变量时，与最低OBS组相比，最高OBS组的女性不孕症发生率降低了60%（OR，0.40；95%CI，0.21至0.74）。此外，亚组分析表明，在非慢性疾病（高血压和糖尿病）人群、高中以下学历人群、贫困收入比（1至3）人群以及年龄超过30岁的人群中，OBS与不孕症之间的负相关关系显著。
较高的OBS与女性不孕症呈负相关。需要进一步开展前瞻性研究以确定因果关系，并从饮食和生活方式的角度为女性不孕症提供新的见解。
