Zeng Xiancheng, Wang Xiane, Guan Xiaoyuan, Feng Xianghui, Lu Ruifang, Meng Huanxin
Department of Periodontology, Peking University School and Hospital of Stomatology, Beijing, China.
National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China.
J Periodontal Res. 2024 Aug;59(4):689-697. doi: 10.1111/jre.13251. Epub 2024 Mar 19.
Periodontitis is characterized by local inflammatory conditions in the periodontium, its severe form has been associated with elevated systemic inflammatory markers. However, the long-term effects of periodontal inflammation control on systemic inflammatory markers are unclear.
This study aimed to investigate the long-term effects of periodontal therapy on the levels of peripheral venous blood inflammatory markers in patients with generalized aggressive periodontitis (GAgP), all of whom were now diagnosed as Stage III or IV Grade C periodontitis.
Patients with GAgP were consecutively recruited from April 2013 to August 2014 (T0). Active periodontal treatment (APT) was provided, and follow-ups were conducted over a 3- to 5-year period (T1). Clinical parameters were assessed and fasting venous blood was collected at T0 and T1. Complete blood cell counts were obtained, and biochemical analyses were performed to evaluate the levels of serum components. The correlations between probing depth (PD) and hematological parameters were analyzed.
A total of 49 patients with GAgP completed APT and follow-ups. Probing depth (PD) reduced from 5.10 ± 1.07 mm at T0 to 3.15 ± 0.65 mm at T1. For every 1-mm reduction in PD after treatment, the neutrophil count, neutrophil-lymphocyte ratio, and total protein concentration were reduced by 0.33 × 10/L, 0.26, and 1.18 g/L, respectively. In contrast, the albumin/globulin ratio increased by 0.10.
This study indicated that periodontal therapy may have beneficial effects on peripheral venous blood inflammatory markers in patients with GAgP during long-term observation.
牙周炎的特征是牙周组织出现局部炎症，其严重形式与全身炎症标志物升高有关。然而，牙周炎症控制对全身炎症标志物的长期影响尚不清楚。
本研究旨在调查牙周治疗对广泛侵袭性牙周炎（GAgP）患者外周静脉血炎症标志物水平的长期影响，所有患者目前均被诊断为III期或IV期C级牙周炎。
2013年4月至2014年8月连续招募GAgP患者（T0）。进行了积极的牙周治疗（APT），并在3至5年期间进行随访（T1）。在T0和T1评估临床参数并采集空腹静脉血。获得全血细胞计数，并进行生化分析以评估血清成分水平。分析探诊深度（PD）与血液学参数之间的相关性。
共有49例GAgP患者完成了APT和随访。探诊深度（PD）从T0时的5.10±1.07mm降至T1时的3.15±0.65mm。治疗后PD每降低1mm，中性粒细胞计数、中性粒细胞与淋巴细胞比值和总蛋白浓度分别降低0.33×10/L、0.26和1.18g/L。相比之下，白蛋白/球蛋白比值增加0.10。
本研究表明，在长期观察期间，牙周治疗可能对GAgP患者外周静脉血炎症标志物有有益影响。
