认知记忆功能障碍与海马亚区体积相关：认知正常和轻度认知障碍老年人的研究。
Recognition Memory Dysfunction Relates to Hippocampal Subfield Volume: A Study of Cognitively Normal and Mildly Impaired Older Adults.
机构信息
Department of Psychology, University of California, Riverside.
Department of Neurobiology and Behavior, University of California, Irvine.
出版信息
J Gerontol B Psychol Sci Soc Sci. 2019 Sep 15;74(7):1132-1141. doi: 10.1093/geronb/gbx181.
OBJECTIVES
The current study examined recognition memory dysfunction and its neuroanatomical substrates in cognitively normal older adults and those diagnosed with mild cognitive impairment (MCI).
METHODS
Participants completed the Mnemonic Similarity Task, which provides simultaneous measures of recognition memory and mnemonic discrimination. They also underwent structural neuroimaging to assess volume of medial temporal cortex and hippocampal subfields.
RESULTS
As expected, individuals diagnosed with MCI had significantly worse recognition memory performance and reduced volume across medial temporal cortex and hippocampal subfields relative to cognitively normal older adults. After controlling for diagnostic group differences, however, recognition memory was significantly related to whole hippocampus volume, and to volume of the dentate gyrus/CA3 subfield in particular. Recognition memory was also related to mnemonic discrimination, a fundamental component of episodic memory that has previously been linked to dentate gyrus/CA3 structure and function.
DISCUSSION
Results reveal that hippocampal subfield volume is sensitive to individual differences in recognition memory in older adults independent of clinical diagnosis. This supports the notion that episodic memory declines along a continuum within this age group, not just between diagnostic groups.
目的
本研究旨在探究认知正常的老年人和轻度认知障碍（MCI）患者的识别记忆功能障碍及其神经解剖学基础。
方法
参与者完成了记忆相似性任务，该任务同时提供识别记忆和记忆辨别力的测量。他们还接受了结构神经影像学检查，以评估内侧颞叶皮质和海马亚区的体积。
结果
正如预期的那样，与认知正常的老年人相比，被诊断为 MCI 的个体的识别记忆表现明显更差，且在内侧颞叶皮质和海马亚区的体积也更小。然而，在控制了诊断组差异后，识别记忆与整个海马体体积显著相关，特别是与齿状回/CA3 亚区的体积相关。识别记忆也与记忆辨别力相关，记忆辨别力是情景记忆的一个基本组成部分，先前与齿状回/CA3 的结构和功能有关。
讨论
结果表明，海马亚区体积对老年人的识别记忆个体差异敏感，与临床诊断无关。这支持了这样一种观点，即在这个年龄组内，情景记忆沿着一个连续体下降，而不仅仅是在诊断组之间。
Zotero 插件