Selby P J, Heyderman E, Gibbs J, Peckham M J
Br J Cancer. 1979 May;39(5):578-83. doi: 10.1038/bjc.1979.104.
Serial transplantation of an HCG-producing human testicular teratoma in immune-deprived mice is described. The xenografted tumour was compared to the tumour of origin in histology, immunohistochemistry (using an immune peroxidase technique to localize HCG) autoradiography, marker production and growth rate. It is concluded that the xenograft retained the characteristics of the original tumour with the exception of a reduction in HCG-producing elements at transplantation beyond 5 serial passages.
本文描述了在免疫缺陷小鼠中对产生人绒毛膜促性腺激素（HCG）的睾丸畸胎瘤进行连续移植的情况。将异种移植瘤与原发肿瘤在组织学、免疫组织化学（使用免疫过氧化物酶技术定位HCG）、放射自显影、标志物产生及生长速率等方面进行了比较。得出的结论是，除了在连续移植超过5代后产生HCG的成分有所减少外，异种移植瘤保留了原发肿瘤的特征。
