Azargoonjahromi Ali, Abutalebian Fatemeh, Hoseinpour Fatemeh
Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Biotechnology and Medicine, Islamic Azad University of Tehran Central Branch, Tehran, Iran.
Nutr Rev. 2025 Feb 1;83(2):e257-e272. doi: 10.1093/nutrit/nuae025.
Resveratrol (RV) is a natural compound found in grapes, wine, berries, and peanuts and has potential health benefits-namely, neurogenesis improvement. Neurogenesis, which is the process through which new neurons or nerve cells are generated in the brain, occurs in the subventricular zone and hippocampus and is influenced by various factors. RV has been shown to increase neural stem cell proliferation and survival, improving cognitive function in hippocampus-dependent tasks. Thus, to provide a convergent and unbiased conclusion of the available evidence on the correlation between the RV and neurogenesis, a systematic review needs to be undertaken meticulously and with appropriate attention.
This study aimed to systematically review any potential connection between the RV and neurogenesis in animal models.
Based on the particular selection criteria, 8 original animal studies that investigated the relationship between RV and neurogenesis were included. Studies written in English and published in peer-reviewed journals with no restrictions on the starting date of publication on August 17, 2023, were searched in the Google Scholar and PubMed databases. Furthermore, data were extracted and analyzed independently by 2 researchers and then reviewed by a third researcher, and discrepancies were resolved by consensus. This project followed PRISMA reporting standards.
In the studies analyzed in this review, there is a definite correlation between RV and neurogenesis, meaning that RV intake, irrespective of the mechanisms thereof, can boost neurogenesis in both the subventricular zone and hippocampus.
This finding, albeit with some limitations, provides a plausible indication of RV's beneficial function in neurogenesis. Indeed, RV intake may result in neurogenesis benefits-namely, cognitive function, mood regulation, stress resilience, and neuroprotection, potentially preventing cognitive decline.
白藜芦醇（RV）是一种存在于葡萄、葡萄酒、浆果和花生中的天然化合物，具有潜在的健康益处，即改善神经发生。神经发生是大脑中产生新神经元或神经细胞的过程，发生在脑室下区和海马体中，并受多种因素影响。已表明RV可增加神经干细胞的增殖和存活，改善依赖海马体的任务中的认知功能。因此，为了对关于RV与神经发生之间相关性的现有证据得出一致且无偏倚的结论，需要精心且适当地进行系统综述。
本研究旨在系统综述动物模型中RV与神经发生之间的任何潜在联系。
根据特定的选择标准，纳入了8项研究RV与神经发生关系的原始动物研究。在谷歌学术和PubMed数据库中搜索了用英文撰写并发表在同行评审期刊上、对2023年8月17日之前的发表起始日期无限制的研究。此外，由2名研究人员独立提取和分析数据，然后由第三名研究人员进行审核，通过协商解决差异。本项目遵循PRISMA报告标准。
在本综述分析的研究中，RV与神经发生之间存在明确的相关性，这意味着无论其机制如何，摄入RV均可促进脑室下区和海马体中的神经发生。
这一发现尽管存在一些局限性，但为RV在神经发生中的有益作用提供了合理的迹象。事实上，摄入RV可能会带来神经发生方面的益处，即认知功能、情绪调节、应激恢复力和神经保护，有可能预防认知能力下降。
