白藜芦醇在神经发生中的作用：一项系统综述。

The role of resveratrol in neurogenesis: a systematic review.

作者信息

Azargoonjahromi Ali, Abutalebian Fatemeh, Hoseinpour Fatemeh

机构信息

Shiraz University of Medical Sciences, Shiraz, Iran.

Department of Biotechnology and Medicine, Islamic Azad University of Tehran Central Branch, Tehran, Iran.

出版信息

Nutr Rev. 2025 Feb 1;83(2):e257-e272. doi: 10.1093/nutrit/nuae025.

DOI:10.1093/nutrit/nuae025

PMID:38511504

Abstract

CONTEXT

Resveratrol (RV) is a natural compound found in grapes, wine, berries, and peanuts and has potential health benefits-namely, neurogenesis improvement. Neurogenesis, which is the process through which new neurons or nerve cells are generated in the brain, occurs in the subventricular zone and hippocampus and is influenced by various factors. RV has been shown to increase neural stem cell proliferation and survival, improving cognitive function in hippocampus-dependent tasks. Thus, to provide a convergent and unbiased conclusion of the available evidence on the correlation between the RV and neurogenesis, a systematic review needs to be undertaken meticulously and with appropriate attention.

OBJECTIVE

This study aimed to systematically review any potential connection between the RV and neurogenesis in animal models.

DATA SOURCES AND EXTRACTION

Based on the particular selection criteria, 8 original animal studies that investigated the relationship between RV and neurogenesis were included. Studies written in English and published in peer-reviewed journals with no restrictions on the starting date of publication on August 17, 2023, were searched in the Google Scholar and PubMed databases. Furthermore, data were extracted and analyzed independently by 2 researchers and then reviewed by a third researcher, and discrepancies were resolved by consensus. This project followed PRISMA reporting standards.

DATA ANALYSIS

In the studies analyzed in this review, there is a definite correlation between RV and neurogenesis, meaning that RV intake, irrespective of the mechanisms thereof, can boost neurogenesis in both the subventricular zone and hippocampus.

CONCLUSION

This finding, albeit with some limitations, provides a plausible indication of RV's beneficial function in neurogenesis. Indeed, RV intake may result in neurogenesis benefits-namely, cognitive function, mood regulation, stress resilience, and neuroprotection, potentially preventing cognitive decline.

摘要

背景

白藜芦醇（RV）是一种存在于葡萄、葡萄酒、浆果和花生中的天然化合物，具有潜在的健康益处，即改善神经发生。神经发生是大脑中产生新神经元或神经细胞的过程，发生在脑室下区和海马体中，并受多种因素影响。已表明RV可增加神经干细胞的增殖和存活，改善依赖海马体的任务中的认知功能。因此，为了对关于RV与神经发生之间相关性的现有证据得出一致且无偏倚的结论，需要精心且适当地进行系统综述。

目的

本研究旨在系统综述动物模型中RV与神经发生之间的任何潜在联系。

数据来源与提取

根据特定的选择标准，纳入了8项研究RV与神经发生关系的原始动物研究。在谷歌学术和PubMed数据库中搜索了用英文撰写并发表在同行评审期刊上、对2023年8月17日之前的发表起始日期无限制的研究。此外，由2名研究人员独立提取和分析数据，然后由第三名研究人员进行审核，通过协商解决差异。本项目遵循PRISMA报告标准。