Department of Infectious Diseases, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China.
2 Beijing Key Laboratory of Basic Research with Traditional Chinese Medicine on Infectious Diseases, Beijing 100010, China.
J Tradit Chin Med. 2024 Apr;44(2):408-416. doi: 10.19852/j.cnki.jtcm.20240203.002.
Sepsis-associated encephalopathy (SAE) is a common manifestation of sepsis, ranging from mild confusion and delirium to severe cognitive impairment and deep coma. SAE is associated with higher mortality and long-term outcomes, particularly substantial declines in cognitive function. The mechanisms of SAE probably include neuroinflammation that is mediated by systemic inflammation and ischemic lesions in the brain, a disrupted blood-brain barrier, oxidative stress, neurotransmitter dysfunction, and severe microglial activation. Increasing evidence suggests that complementary and alternative medicine, especially Traditional Chinese Medicine (TCM), is favorable in alleviating cognitive decline after sepsis. Here, we summarized the studies of traditional herbal remedies, TCM formulas and acupuncture therapy in animal models of neurological dysfunctions after sepsis in recent decades and reviewed their potential mechanisms.
脓毒症相关性脑病（SAE）是脓毒症的一种常见表现，从轻度意识混乱和昏迷到严重认知障碍和深度昏迷不等。SAE 与更高的死亡率和长期预后相关，特别是认知功能的显著下降。SAE 的机制可能包括由全身炎症和脑缺血病变介导的神经炎症、血脑屏障破坏、氧化应激、神经递质功能障碍和严重的小胶质细胞激活。越来越多的证据表明，补充和替代医学，特别是中医药（TCM），在缓解脓毒症后认知能力下降方面具有优势。在这里，我们总结了近几十年来在脓毒症后神经功能障碍动物模型中传统草药、中药方剂和针灸治疗的研究，并综述了其潜在机制。
