用于生物样品力学测量的微流控技术。
Microfluidic techniques for mechanical measurements of biological samples.
作者信息
Salipante Paul F
机构信息
National Institute of Standards and Technology, Polymers and Complex Fluids Group, Gaithersburg, Maryland 20899, USA.
出版信息
Biophys Rev (Melville). 2023 Jan 20;4(1):011303. doi: 10.1063/5.0130762. eCollection 2023 Mar.
The use of microfluidics to make mechanical property measurements is increasingly common. Fabrication of microfluidic devices has enabled various types of flow control and sensor integration at micrometer length scales to interrogate biological materials. For rheological measurements of biofluids, the small length scales are well suited to reach high rates, and measurements can be made on droplet-sized samples. The control of flow fields, constrictions, and external fields can be used in microfluidics to make mechanical measurements of individual bioparticle properties, often at high sampling rates for high-throughput measurements. Microfluidics also enables the measurement of bio-surfaces, such as the elasticity and permeability properties of layers of cells cultured in microfluidic devices. Recent progress on these topics is reviewed, and future directions are discussed.
利用微流控技术进行力学性能测量正变得越来越普遍。微流控设备的制造使得在微米长度尺度上实现各种类型的流量控制和传感器集成，从而能够对生物材料进行检测。对于生物流体的流变学测量，小长度尺度非常适合达到高流速，并且可以对液滴大小的样本进行测量。微流控技术中可以通过控制流场、收缩和外部场来对单个生物颗粒的特性进行力学测量，通常以高通量测量的高采样率进行。微流控技术还能够测量生物表面，例如在微流控设备中培养的细胞层的弹性和渗透性等特性。本文综述了这些主题的最新进展，并讨论了未来的发展方向。
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