Boucheta Hana, Zouaoui Emna, Ferkous Hana, Madaci Anis, Yadav Krishna Kumar, Benguerba Yacine
Laboratory of Physico-Chemistry Research on Surfaces and Interfaces, University of 20 August 1955, Skikda, Algeria.
Department of Process Engineering, Faculty of Technology, University of 20 August 1955, Skikda, Algeria.
J Diabetes Sci Technol. 2024 Mar 20:19322968241236211. doi: 10.1177/19322968241236211.
Glucose is vital for biological processes, requiring blood sugar levels to be maintained between 3.88 and 6.1 mmol/L, especially during fasting. Elevated levels signal diabetes, a global concern affecting 537 million people, necessitating effective glucose-monitoring devices.
Enzyme-based sensors, though selective, are sensitive to environmental factors. Nonenzymatic sensors, especially those with nanoparticles, offer stability, high surface area, and cost-effectiveness. Existing literature supports their immediate glucose oxidation, showcasing exceptional sensitivity.
This review details nonenzymatic sensors, highlighting materials, detection limits, and the promise of nanoparticle-based designs, which exhibit enhanced sensitivity and selectivity in glucose detection.
Nanoparticle-based sensors, as reviewed, show potential for glucose monitoring, overcoming enzyme-based limitations. The conclusion suggests future directions for advancing these sensors, emphasizing ongoing innovation in this critical research area.
葡萄糖对生物过程至关重要，要求血糖水平维持在3.88至6.1毫摩尔/升之间，尤其是在禁食期间。血糖水平升高表明患有糖尿病，这是一个影响5.37亿人的全球性问题，因此需要有效的血糖监测设备。
基于酶的传感器虽然具有选择性，但对环境因素敏感。非酶传感器，尤其是那些含有纳米颗粒的传感器，具有稳定性、高表面积和成本效益。现有文献支持它们能立即进行葡萄糖氧化，显示出卓越的灵敏度。
本综述详细介绍了非酶传感器，重点介绍了材料、检测限以及基于纳米颗粒设计的前景，这些设计在葡萄糖检测中表现出更高的灵敏度和选择性。
如本综述所述，基于纳米颗粒的传感器在血糖监测方面显示出潜力，克服了基于酶的传感器的局限性。该结论为推进这些传感器的发展提出了未来方向，强调了这一关键研究领域正在进行的创新。
