Sattari Mohammad Amir, Hayati Mohsen
Electrical Engineering Department, Faculty of Engineering, Razi University, Kermanshah, Iran.
Sci Rep. 2025 Jul 2;15(1):22937. doi: 10.1038/s41598-025-06502-y.
Monitoring of fasting blood sugar (FBS) is a critical component in the diagnosis and management of diabetes, one of the most widespread chronic diseases globally. Microwave sensing-particularly through microstrip-based sensors-has recently gained attention as a promising technique for blood glucose monitoring, offering advantages such as low cost, high sensitivity, real-time response capability, and suitability for compact and wearable systems. In this study, a miniaturized microstrip microwave sensor is presented for non-contact FBS detection. Blood samples were directly collected from 78 individuals and analyzed using a clinical-grade auto-chemistry analyzer to determine reference FBS levels. Each sample was measured five times on the microwave sensor, resulting in a total of 390 transmission responses (S21) across a frequency range of 30 kHz to 18 GHz. These responses were recorded under controlled laboratory conditions, ensuring consistency and minimizing environmental interference. To interpret the complex, non-linear features of the sensor response, a convolutional neural network (CNN) was developed and trained using the entire dataset. The network demonstrated highly promising performance in estimating FBS values, achieving a mean relative error (MRE) of 1.31%. The results confirm the feasibility of combining broadband microwave sensing with deep learning techniques to enable reliable non-contact blood glucose measurement. This approach holds strong potential for integration into future wearable health monitoring systems, providing more user-friendly diabetic management tools without the frequent use of conventional blood sampling techniques.
空腹血糖(FBS)监测是糖尿病诊断和管理的关键组成部分,糖尿病是全球最普遍的慢性疾病之一。微波传感——特别是通过基于微带的传感器——最近作为一种有前景的血糖监测技术受到关注,具有低成本、高灵敏度、实时响应能力以及适用于紧凑和可穿戴系统等优点。在本研究中,提出了一种用于非接触式FBS检测的小型化微带微波传感器。直接从78名个体采集血样,并使用临床级自动化学分析仪进行分析,以确定参考FBS水平。每个样本在微波传感器上测量五次,在30 kHz至18 GHz的频率范围内总共得到390个传输响应(S21)。这些响应在受控实验室条件下记录,以确保一致性并最小化环境干扰。为了解释传感器响应的复杂非线性特征,开发了一个卷积神经网络(CNN)并使用整个数据集进行训练。该网络在估计FBS值方面表现出非常有前景的性能,平均相对误差(MRE)为1.31%。结果证实了将宽带微波传感与深度学习技术相结合以实现可靠的非接触式血糖测量的可行性。这种方法具有很强的潜力可集成到未来的可穿戴健康监测系统中,提供更用户友好的糖尿病管理工具,而无需频繁使用传统的采血技术。