暴露于环境温度和热指数与 DNA 甲基化年龄的关系：基于人群的台湾研究。

Exposure to ambient temperature and heat index in relation to DNA methylation age: A population-based study in Taiwan.

机构信息

Institute of Environmental and Occupational Health Sciences, College of Public Health, National Taiwan University, Taipei, Taiwan.

Department of Emergency Medicine, Taipei Veterans General Hospital, Taoyuan Branch, Taoyuan, Taiwan; Department of Emergency Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.

出版信息

Environ Int. 2024 Apr;186:108581. doi: 10.1016/j.envint.2024.108581. Epub 2024 Mar 17.

DOI:10.1016/j.envint.2024.108581

PMID:38507934

Abstract

BACKGROUND

Climate change caused an increase in ambient temperature in the past decades. Exposure to high ambient temperature could result in biological aging, but relevant studies in a warm environment were lacking. We aimed to study the exposure effects of ambient temperature and heat index (HI) in relation to age acceleration in Taiwan, a subtropical island in Asia.

METHODS

The study included 2,084 participants from Taiwan Biobank. Daily temperature and relative humidity data were collected from weather monitoring stations. Individual residential exposure was estimated by ordinary kriging. Moving averages of ambient temperature and HI from 1 to 180 days prior to enrollment were calculated to estimate the exposure effects in multiple time periods. Age acceleration was defined as the difference between DNA methylation age and chronological age. DNA methylation age was calculated by the Horvath's, Hannum's, Weidner's, ELOVL2, FHL2, phenotypic (Pheno), Skin & blood, and GrimAge2 (Grim2) DNA methylation age algorithms. Multivariable linear regression models, generalized additive models (GAMs), and distributed lag non-linear models (DLNMs) were conducted to estimate the effects of ambient temperature and HI exposures in relation to age acceleration.

RESULTS

Exposure to high ambient temperature and HI were associated with increased age acceleration, and the associations were stronger in prolonged exposure. The heat stress days with maximum HI in caution (80-90°F), extreme caution (90-103°F), danger (103-124°F), and extreme danger (>124°F) were also associated with increased age acceleration, especially in the extreme danger days. Each extreme danger day was associated with 571.38 (95 % CI: 42.63-1100.13), 528.02 (95 % CI: 36.16-1019.87), 43.9 (95 % CI: 0.28-87.52), 16.82 (95 % CI: 2.36-31.28) and 15.52 (95 % CI: 2.17-28.88) days increase in the Horvath's, Hannum's, Weidner's, Pheno, and Skin & blood age acceleration, respectively.

CONCLUSION

High ambient temperature and HI may accelerate biological aging.

摘要

背景

在过去几十年中，气候变化导致环境温度升高。暴露于高温环境中可能导致生物衰老，但在温暖环境中相关研究较少。我们旨在研究环境温度和热指数（HI）暴露与亚洲亚热带岛屿台湾的年龄加速之间的关系。

方法

这项研究包括来自台湾生物银行的 2084 名参与者。从气象监测站收集每日温度和相对湿度数据。通过普通克里金法估计个体住宅暴露情况。计算入组前 1 至 180 天的环境温度和 HI 的移动平均值，以在多个时间段内估计暴露效应。年龄加速定义为 DNA 甲基化年龄与实际年龄之间的差异。DNA 甲基化年龄通过 Horvath、Hannum、Weidner、ELOVL2、FHL2、表型（Pheno）、皮肤和血液以及 GrimAge2（Grim2）DNA 甲基化年龄算法计算得出。使用多变量线性回归模型、广义加性模型（GAMs）和分布式滞后非线性模型（DLNMs）来估计环境温度和 HI 暴露与年龄加速之间的关系。

结果

暴露于高温和 HI 与年龄加速增加有关，并且在长时间暴露时，这种关联更强。谨慎（80-90°F）、极端谨慎（90-103°F）、危险（103-124°F）和极度危险（>124°F）的最大 HI 热应激天数也与年龄加速增加有关，尤其是在极度危险的日子里。每个极度危险日与 Horvath 的 571.38（95%CI：42.63-1100.13）、528.02（95%CI：36.16-1019.87）、43.9（95%CI：0.28-87.52）、16.82（95%CI：2.36-31.28）和 15.52（95%CI：2.17-28.88）天的年龄加速增加有关，以及 Hannum、Weidner、Pheno 和 Skin & blood 的年龄加速。