Nutrition Health Research Center, Hamadan University of Medical Sciences, Hamadan, Iran; Department of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Institute of Polymers, Composites, and Biomaterials, National Research Council (IPCB-CNR), Naples 80125, Italy; Department of Chemical, Materials and Production Engineering, University of Naples Federico II, Piazzale V. Tecchio 80, Naples 80125, Italy.
Biomed Pharmacother. 2024 May;174:116433. doi: 10.1016/j.biopha.2024.116433. Epub 2024 Mar 19.
Nano pharmacology is considered an effective, safe, and applicable approach for drug delivery applications. Solid lipid nanoparticle (SLNs) colloids contain biocompatible lipids which are capable of encapsulating and maintaining hydrophilic or hydrophobic drugs in the solid matrix followed by releasing the drug in a sustained manner in the target site. SLNs have more promising potential than other drug delivery systems for various purposes. Nowadays, the SLNs are used as a carrier for antibiotics, chemotherapeutic drugs, nucleic acids, herbal compounds, etc. The SLNs have been widely applied in biomedicine because of their non-toxicity, biocompatibility, and simple production procedures. In this review, the complications related to the optimization, preparation process, routes of transplantation, uptake and delivery system, and release of the loaded drug along with the advantages of SLNs as therapeutic agents were discussed.
纳米药理学被认为是一种有效的、安全的、适用的药物传递方法。固体脂质纳米粒 (SLN) 胶体含有生物相容性脂质，能够将亲水性或疏水性药物包裹并保持在固体基质中，然后以持续的方式在靶部位释放药物。SLN 比其他药物传递系统具有更有前途的潜力，可用于各种目的。如今，SLN 已被用作抗生素、化疗药物、核酸、草药化合物等的载体。由于其无毒、生物相容性和简单的生产工艺，SLN 已广泛应用于生物医学领域。在本文综述中，讨论了与优化、制备工艺、移植途径、摄取和递药系统以及负载药物的释放相关的并发症，以及 SLN 作为治疗剂的优点。
