Institute of Biomedical Engineering, Federal University of Santa Catarina, Florianópolis, 88040-900, SC, Brazil.
Institute of Biomedical Engineering, Federal University of Santa Catarina, Florianópolis, 88040-900, SC, Brazil; Department of Control and Automation Engineering, Federal University of Santa Catarina, Blumenau, 89036-004, SC, Brazil.
Med Eng Phys. 2024 Mar;125:104120. doi: 10.1016/j.medengphy.2024.104120. Epub 2024 Feb 21.
Electrochemotherapy is a cancer treatment in which local pulsed electric fields are delivered through electrodes. The effectiveness of the treatment depends on exposing the tumor to a threshold electric field. Electrode geometry plays an important role in the resulting electric field distribution, especially in hard-to-reach areas and deep-seated tumors. We designed and developed a novel tetrapolar single-needle electrode for proper treatment in bone cavities. In silico and in vitro experiments were performed to evaluate the electric field and electric current produced by the electrode. In addition, tomography images of a real case of nasal cavity tumor were segmented into a 3D simulation to evaluate the electrode performance in a bone cavity. The proposed electrode was validated and its operating range was set up to 650 V. In the nasal cavity tumor, we found that the electrode can produce a circular electric field of 3 mm with an electric current of 14.1 A at 500 V, which is compatible with electrochemotherapy standards and commercial equipment.
电化学疗法是一种通过电极施加局部脉冲电场的癌症治疗方法。该治疗的有效性取决于将肿瘤暴露于阈值电场。电极几何形状在产生的电场分布中起着重要作用，尤其是在难以触及的区域和深部肿瘤中。我们设计并开发了一种新型的四极单针电极，用于在骨腔中进行适当的治疗。进行了数值模拟和体外实验，以评估电极产生的电场和电流。此外，对鼻腔肿瘤的真实病例的断层扫描图像进行了分割，以在骨腔中评估电极的性能。验证了所提出的电极，并确定了其工作范围为 650V。在鼻腔肿瘤中，我们发现该电极可以在 500V 时产生 3mm 的圆形电场，电流为 14.1A，这与电化学疗法的标准和商业设备兼容。
