Vera-Tizatl Adriana Leticia, Vera-Tizatl Claudia Elizabeth, Vera-Hernández Arturo, Leija-Salas Lorenzo, Rodríguez Sergio, Miklavčič Damijan, Kos Bor
1 Department of Electrical Engineering, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), Mexico City, Mexico.
2 Department of Infectomics and Molecular Pathogenesis, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), Mexico City, Mexico.
Technol Cancer Res Treat. 2018 Jan 1;17:1533033818794939. doi: 10.1177/1533033818794939.
Breast cancer represents a rising problem concerning public health worldwide. Current efforts are aimed to the development of new minimally invasive and conservative treatment procedures for this disease. A treatment approach for invasive breast ductal carcinoma could be based on electroporation. Hence, in order to determine the effectiveness of electrochemotherapy in the treatment of this disease, 12 electrode models were investigated on realistic patient-specific computational breast models of 3 patients diagnosed by Digital Breast Tomosynthesis imaging. The electrode models exhibit 4, 5, and 6 needles arranged in 4 geometric configurations (delta, diamond, and star) and 3 different needle spacing resulting in a total of 12 needle-electrode arrays. Electric field distribution in the tumors and a surrounding safety margin of 1 cm around the tumor edge is computed using the finite element method. Efficiency of the electrode arrays was determined hierarchically based on (1) percentage of tumor volume reversibly electroporated, (2) percentage of tumor volume irreversibly electroporated, (3) percentage of treated safety margin volume, (4) minimal invasiveness, that is, minimal number of electrodes used, (5) minimal activated electrode pairs, and (6) minimal electric current. Results show that 3 electrode arrays (4 needle-delta, 5 needle-diamond, and 6 needle-star) with fixed-geometry configuration could be used in the treatment with electrochemotherapy of invasive breast ductal carcinomas ranging from 1 to 5 cm along with a surrounding safety margin of 1 cm.
乳腺癌是一个在全球范围内日益引起公众健康关注的问题。目前的努力旨在开发针对这种疾病的新型微创和保守治疗方法。浸润性乳腺导管癌的一种治疗方法可以基于电穿孔。因此，为了确定电化学疗法在治疗这种疾病中的有效性，在通过数字乳腺断层合成成像诊断的3名患者的真实患者特异性计算乳腺模型上研究了12种电极模型。电极模型呈现出4种、5种和6种针，排列成4种几何构型（三角形、菱形和星形）以及3种不同的针间距，总共产生12种针电极阵列。使用有限元方法计算肿瘤内以及肿瘤边缘周围1厘米安全边缘内的电场分布。基于以下因素分层确定电极阵列的效率：（1）可逆电穿孔的肿瘤体积百分比，（2）不可逆电穿孔的肿瘤体积百分比，（3）治疗的安全边缘体积百分比，（4）最小侵入性，即使用的电极数量最少，（5）最少的激活电极对，以及（6）最小电流。结果表明，具有固定几何构型的3种电极阵列（4针三角形、5针菱形和6针星形）可用于电化学疗法治疗直径为1至5厘米且周围有1厘米安全边缘的浸润性乳腺导管癌。
