Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland; INFANT Research Centre, University College Cork, Cork, Ireland; APC Microbiome Ireland, University College Cork, Cork, Ireland.
Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland; INFANT Research Centre, University College Cork, Cork, Ireland.
Trends Neurosci. 2024 Apr;47(4):259-272. doi: 10.1016/j.tins.2024.02.001. Epub 2024 Mar 19.
Middle age has historically been an understudied period of life compared to older age, when cognitive and brain health decline are most pronounced, but the scope for intervention may be limited. However, recent research suggests that middle age could mark a shift in brain aging. We review emerging evidence on multiple levels of analysis indicating that midlife is a period defined by unique central and peripheral processes that shape future cognitive trajectories and brain health. Informed by recent developments in aging research and lifespan studies in humans and animal models, we highlight the utility of modeling non-linear changes in study samples with wide subject age ranges to distinguish life stage-specific processes from those acting linearly throughout the lifespan.
与认知和大脑健康衰退最明显的老年相比，中年在历史上一直是研究较少的时期，但干预的范围可能有限。然而，最近的研究表明，中年可能标志着大脑衰老的转变。我们回顾了多个分析层面的新兴证据，这些证据表明，中年是一个由独特的中枢和外周过程定义的时期，这些过程塑造了未来的认知轨迹和大脑健康。借鉴最近在人类和动物模型衰老研究和寿命研究方面的进展，我们强调了在具有广泛受试者年龄范围的研究样本中对非线性变化进行建模的效用，以区分特定生命阶段的过程与整个生命周期线性作用的过程。
