Hurley Michael J, Garduño B Maximiliano, Deacon Robert M J, Holmes Todd C, Xu Xiangmin, Cogram Patricia
Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Queen Square, London, UK.
IEB, Faculty of Sciences, University of Chile, Santiago, Chile.
Lab Anim (NY). 2025 Sep;54(9):219-222. doi: 10.1038/s41684-025-01602-8.
The study of aging and age-related diseases has traditionally focused on short-lived laboratory species such as mice. The common degu () is a long-lived rodent species native to Chile that naturally develops neuropathology and behavioral deficits characteristic of Alzheimer’s disease together with other comorbidities associated with aging. These characteristics make the degu a useful model to gain insights into the interaction of aging and neurodegeneration.
传统上，衰老及与年龄相关疾病的研究主要集中在小鼠等寿命较短的实验动物身上。普通八齿鼠是一种原产于智利的长寿啮齿动物，它会自然出现阿尔茨海默病特有的神经病理学和行为缺陷，以及与衰老相关的其他合并症。这些特征使八齿鼠成为了解衰老与神经退行性变相互作用的有用模型。
