西咪替丁治疗伴有消化性狭窄的反流性食管炎。
Cimetidine in treatment of reflux oesophagitis with peptic stricture.
作者信息
Ferguson R, Dronfield M W, Atkinson M
出版信息
Br Med J. 1979 Aug 25;2(6188):472-4. doi: 10.1136/bmj.2.6188.472.
Abstract
Twenty patients with reflux oesophagitis causing a tight peptic oesophageal stricture entered a randomised double-blind crossover trial in which they received cimetidine, 1.6 g daily, and matching placebo each for six months. The gross endoscopic appearances of oesophagitis, though not the grades of histopathological changes, showed significant improvement during treatment with cimetidine. The need for dilatation of the strictures, however, was not reduced.
摘要
20例因反流性食管炎导致食管消化性狭窄的患者进入一项随机双盲交叉试验，他们分别接受每日1.6克西咪替丁和匹配的安慰剂治疗，各为期6个月。食管炎的内镜大体表现虽未显示组织病理学改变的分级情况，但在西咪替丁治疗期间有显著改善。然而，狭窄扩张的需求并未减少。
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本文引用的文献
1
Oral cimetidine in reflux esophagitis: a double blind controlled trial.口服西咪替丁治疗反流性食管炎：一项双盲对照试验。
Gastroenterology. 1978 May;74(5 Pt 1):821-4.
2
Cimetidine in the treatment of symptomatic gastroesophageal reflux: a double blind controlled trial.西咪替丁治疗症状性胃食管反流：一项双盲对照试验。
Gastroenterology. 1978 Feb;74(2 Pt 2):441-8.
3
Effect of cimetidine in symptomatic gastro-oesophageal reflux.
Lancet. 1978 Nov 18;2(8099):1068-9. doi: 10.1016/s0140-6736(78)91802-0.
4
Esophageal intraluminal pH recording in the assessment of gastroesophageal reflux and its consequences.
Am J Dig Dis. 1977 Apr;22(4):365-70. doi: 10.1007/BF01072195.
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