Kumar Vimal, Barwal Arti, Sharma Nitin, Mir Danish Shafi, Kumar Pradeep, Kumar Vikas
University Institute of Biotechnology, Chandigarh University, Gharuan, Mohali, Punjab 140413 India.
Department of Microbial Biotechnology, Panjab University, South Campus, Sector-25, Chandigarh, 160014 India.
3 Biotech. 2024 Apr;14(4):112. doi: 10.1007/s13205-024-03958-z. Epub 2024 Mar 18.
Proteins are considered magic molecules due to their enormous applications in the health sector. Over the past few decades, therapeutic proteins have emerged as a promising treatment option for various diseases, particularly cancer, cardiovascular disease, diabetes, and others. The formulation of protein-based therapies is a major area of research, however, a few factors still hinder the large-scale production of these therapeutic products, such as stability, heterogenicity, immunogenicity, high cost of production, etc. This review provides comprehensive information on various sources and production of therapeutic proteins. The review also summarizes the challenges currently faced by scientists while developing protein-based therapeutics, along with possible solutions. It can be concluded that these proteins can be used in combination with small molecular drugs to give synergistic benefits in the future.
由于蛋白质在健康领域有着广泛应用，它们被视为神奇的分子。在过去几十年里，治疗性蛋白质已成为治疗各种疾病（尤其是癌症、心血管疾病、糖尿病等）的一种有前景的治疗选择。基于蛋白质的疗法的配方是一个主要研究领域，然而，一些因素仍阻碍着这些治疗产品的大规模生产，如稳定性、异质性、免疫原性、高生产成本等。本综述提供了关于治疗性蛋白质的各种来源和生产的全面信息。该综述还总结了科学家在开发基于蛋白质的疗法时目前面临的挑战以及可能的解决方案。可以得出结论，这些蛋白质未来可与小分子药物联合使用以产生协同效益。
