Roy Raymond, D'Angiulli Amedeo
Department of Neuroscience, Carleton University, Ottawa, ON, Canada.
Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.
Front Neurosci. 2024 Mar 6;18:1351721. doi: 10.3389/fnins.2024.1351721. eCollection 2024.
This paper delves into the increasingly recognized yet complex relationship between air pollution and Neurological Diseases. Although the detrimental effects of air pollution on respiratory and cardiovascular health are well-documented, its impact on neurological and cognitive disorders is an emerging area of concern. In this mini review, we explore the intricate mechanisms by which various air pollutants, such as particulate matter, nitrogen oxides, and polycyclic aromatic hydrocarbons, contribute to neurological pathologies. The focus lies on the role of oxidative stress and inflammation in exacerbating conditions like Alzheimer's disease and Parkinson's disease. By unraveling these connections, the paper sheds light on the broader implications of environmental factors on neurological health and underscores the urgent need for policy interventions to mitigate air pollution's impact on the nervous system.
本文深入探讨了空气污染与神经系统疾病之间日益受到认可但却复杂的关系。尽管空气污染对呼吸道和心血管健康的有害影响已有充分记录,但其对神经和认知障碍的影响却是一个新出现的令人关注的领域。在这篇小型综述中,我们探究了各种空气污染物,如颗粒物、氮氧化物和多环芳烃,导致神经病理学的复杂机制。重点在于氧化应激和炎症在加剧阿尔茨海默病和帕金森病等病症方面的作用。通过揭示这些联系,本文阐明了环境因素对神经健康的更广泛影响,并强调了采取政策干预措施以减轻空气污染对神经系统影响的迫切需求。