Kang Miran, Yang Kwang Mo, Stanly Christine, Pant Alina
Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Republic of Korea.
ASEAN Institute for Health Development, Mahidol University, Phutthamonthon, Nakhon Pathom, 73170, Thailand.
Mol Biol Rep. 2025 Jun 26;52(1):639. doi: 10.1007/s11033-025-10770-2.
The occurrence of allergic respiratory diseases (ARDs) is increasing worldwide due to hypersensitivity to foreign allergens. Around 40% of the global population is affected by ARDs which are exacerbated by environmental pollution. Furthermore, prolonged ARDs-associated symptoms reduce quality of life and increase the risk of neurological disorders like depression, anxiety disorder, and dementia through oxidative stress-induced neuroinflammation. Recently, plant secondary metabolites (PSMs) have emerged as novel dietary therapeutics, which exhibit potent antioxidant and antiallergic capabilities in treating ARDs. These bioactive compounds, have antimicrobial, antiviral, and antiallergic properties, making them particularly useful in treating respiratory diseases. This review summarizes and discusses the mechanisms of ARDs and how PSMs could be alternative therapeutics for treating ARDs, as well as prospects.
由于对外来过敏原过敏，过敏性呼吸道疾病（ARDs）在全球范围内的发病率正在上升。全球约40%的人口受到ARDs的影响，环境污染会加剧这些疾病。此外，ARDs相关症状的长期存在会降低生活质量，并通过氧化应激诱导的神经炎症增加患抑郁症、焦虑症和痴呆症等神经疾病的风险。最近，植物次生代谢产物（PSMs）已成为新型饮食疗法，在治疗ARDs方面具有强大的抗氧化和抗过敏能力。这些生物活性化合物具有抗菌、抗病毒和抗过敏特性，使其在治疗呼吸道疾病方面特别有用。本综述总结并讨论了ARDs的发病机制以及PSMs如何成为治疗ARDs的替代疗法，以及前景。
