Panigrahi Gunadhar, Goodwin Sally M, Staffier Kara Livingston, Karlsen Micaela
Sentara Cardiology Specialists Wellness Clinic, Sentara Princess Anne Hospital, Virginia Beach, VA, USA.
American College of Lifestyle Medicine, Chesterfield, MO, USA.
Am J Lifestyle Med. 2023 Jun 15;17(6):839-846. doi: 10.1177/15598276231181574. eCollection 2023 Nov-Dec.
Prevalence of type 2 diabetes (T2D) is rising, and its burden on the healthcare system remains a challenge. Consumption of a plant-predominant diet is a promising approach for achieving remission, which has emerged as a therapeutic target. To establish feasibility of achieving T2D remission with a plant-predominant diet in a cohort of free-living individuals. Patients referred to a wellness clinic were treated with a low-fat, whole food, plant-predominant diet while receiving standard medical treatment. Included patients were adults, mostly elderly, with HbA1c > 6.5%, with or without use of antidiabetic medications. N = 59 patients were included in this analysis, with mean age 71.5 years (range 41-89). Twenty-two (37%) patients achieved T2D remission. Mean differences showed a significant decrease post-lifestyle change (T2) compared to prior to lifestyle change (T1) for the following outcomes [least squares mean difference (95% CI)]: BMI [-2.6 (-4.8, -.3)] kg/m; HbA1c [ -1.3 (-1.6, -1.0)] %; and fasting glucose [-29.6 (-41.8, -17.5)] mg/dL. No significant differences were observed for systolic or diastolic blood pressure, HDL, LDL, or triglycerides. A lifestyle-based treatment intervention promoting adherence to a plant-predominant diet and integrated can successfully achieve T2D remission in wellness clinic patients.
2型糖尿病（T2D）的患病率正在上升，其对医疗保健系统的负担仍然是一项挑战。以植物为主的饮食消费是实现缓解的一种有前景的方法，缓解已成为一个治疗目标。为了确定在一群自由生活的个体中采用以植物为主的饮食实现T2D缓解的可行性。转诊至健康诊所的患者在接受标准医疗治疗的同时，采用低脂、全食物、以植物为主的饮食进行治疗。纳入的患者为成年人，大多为老年人，糖化血红蛋白（HbA1c）>6.5%，无论是否使用抗糖尿病药物。本分析纳入了N = 59名患者，平均年龄71.5岁（范围41 - 89岁）。22名（37%）患者实现了T2D缓解。对于以下结果，平均差异显示生活方式改变后（T2）与生活方式改变前（T1）相比有显著下降[最小二乘均值差异（95%置信区间）]：体重指数（BMI）[-2.6（-4.8，-0.3）]kg/m²；HbA1c[-1.3（-1.6，-1.0）]%；空腹血糖[-29.6（-41.8，-17.5）]mg/dL。收缩压或舒张压、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）或甘油三酯未观察到显著差异。一种促进坚持以植物为主的饮食并综合的基于生活方式的治疗干预可以成功地使健康诊所的患者实现T2D缓解。
