纯素饮食可改善肥胖个体的胰岛素抵抗：一项系统评价与荟萃分析。
A vegan diet improves insulin resistance in individuals with obesity: a systematic review and meta-analysis.
作者信息
Chen Peng, Zhao Ying, Chen Yan
机构信息
Department of Pediatrics, The Second Hospital of Jilin University, Changchun, China.
Department of Endocrinology, The Second Hospital of Jilin University, No. 218, Ziqiang Street, Nanguan District, Changchun, China.
出版信息
Diabetol Metab Syndr. 2022 Aug 13;14(1):114. doi: 10.1186/s13098-022-00879-w.
BACKGROUND
A vegan diet has benefits on weight reduction and on the parameters of glucose and lipid metabolism. This meta-analysis aimed to investigate the efficacy of plant-based diets on insulin resistance and blood lipids in patients with obesity.
METHODS
PubMed, Embase, and the Cochrane Library were searched for available papers published up to March 2021. The primary outcome was insulin resistance which was assessed by Homeostasis Model Assessment Insulin Resistance (HOMA-IR), other metabolic parameters measures including the pre/post-diet changes in triglycerides, HDL-cholesterol, total cholesterol, LDL-cholesterol. All analyses were performed using the random-effects model.
RESULTS
Six studies (seven datasets) were included. Compared with baseline, the plant-based diet improved the HOMA-IR (SMD = 1.64, 95%CI 0.95, 2.33; I = 91.8%, P < 0.001), total cholesterol (SMD = 2.51, 95% CI 0.88, 4.13; I = 98.0%, P < 0.001), HDL-cholesterol (SMD = 1.55, 95% CI 0.66, 2.44; I = 92.0%, P < 0.001), and LDL-cholesterol (SMD = 2.50, 95% CI 1.30, 3.70; I = 94.4%, P < 0.001), but not the triglycerides (SMD = - 0.62, 95% CI - 1.92, 0.68; I = 97.8%, P < 0.001). The sensitivity analyses showed that the results were robust.
CONCLUSIONS
In obese individuals with insulin resistance, a vegan diet improves insulin resistance and dyslipidemia, except for triglycerides.
背景
纯素饮食对体重减轻以及糖脂代谢参数有益。本荟萃分析旨在研究植物性饮食对肥胖患者胰岛素抵抗和血脂的疗效。
方法
检索了截至2021年3月发表在PubMed、Embase和Cochrane图书馆的可用论文。主要结局是胰岛素抵抗，通过稳态模型评估胰岛素抵抗（HOMA-IR）进行评估，其他代谢参数指标包括饮食前后甘油三酯、高密度脂蛋白胆固醇、总胆固醇、低密度脂蛋白胆固醇的变化。所有分析均采用随机效应模型。
结果
纳入了六项研究（七个数据集）。与基线相比，植物性饮食改善了HOMA-IR（标准化均数差[SMD]=1.64，95%置信区间[CI]0.95，2.33；I²=91.8%，P<0.001）、总胆固醇（SMD=2.51，95%CI0.88，4.13；I²=98.0%，P<0.001）、高密度脂蛋白胆固醇（SMD=1.55，95%CI0.66，2.44；I²=92.0%，P<0.001）和低密度脂蛋白胆固醇（SMD=2.50，95%CI1.30，3.70；I²=94.4%，P<0.001），但未改善甘油三酯（SMD=-0.62，95%CI-1.92，0.68；I²=97.8%，P<0.001）。敏感性分析表明结果具有稳健性。
结论
在患有胰岛素抵抗的肥胖个体中，纯素饮食可改善胰岛素抵抗和血脂异常，但甘油三酯除外。
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