Tassis Panagiotis, Raj Jog, Floros Dimitrios, Mittas Nikolaos, Ntarampa Niki, Farkas Hunor, Polizopoulou Zoe, Vasilievic Marko
Farm Animals Clinic, School of Veterinary Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Patent Co, DOO., Mišićevo, Serbia.
Front Vet Sci. 2024 Mar 6;11:1357723. doi: 10.3389/fvets.2024.1357723. eCollection 2024.
The study aimed to evaluate the efficacy of a novel multicomponent substance against combined exposure to the mycotoxins zearalenone (ZEN) and ochratoxin A (OTA) in weaned piglets.
In total, 60 piglets at the age of 28 days were equally allocated to four experimental groups (A-D), consisting of eight female and seven male piglets each (15 animals per group, for a total trial duration of 42 days). Animals from group A received typical weaner feed without mycotoxins or the test product [multicomponent mycotoxin detoxifying agent (MMDA)]. Group B animals received the same weaner feed contaminated with 0.992 mg ZEN/kg feed and 0.531 mg OTA/kg feed without the addition of the MMDA. Animals in group C received the same contaminated feed as group B with the addition of 1.5 g MMDA/kg feed, whereas group D received the same feed as group B with the inclusion of 3 g MMDA/kg feed. Clinical signs and performance parameters [body weight (BW), average daily weight gain (ADWG), and feed conversion ratio (FCR)] were evaluated, while mycotoxin residues were also assessed in the liver and kidney tissues.
Findings showed improved FCR in the group that received the greatest dose of the test product (3 g MMDA/kg feed) compared to the group that received the lower dose (1.5 g MMDA/kg feed). A few hematological and biochemical parameters were slightly altered, predominantly within normal limits. The residue analysis demonstrated a reduction of OTA in liver samples, a-ZEL in the liver and total tested samples, and a total of ZEN and metabolite contents in all samples of the group that received the greatest MMDA dose in comparison to the group that received the toxins without the addition of the test product.
Therefore, a positive effect of the MMDA at the greatest dosage regime on reducing bioavailability and tissue deposition of ZEN and OTA, with a particularly positive effect on FCR in weaned pigs, is suggested under concurrent ZEN and OTA exposure .
本研究旨在评估一种新型多组分物质对断奶仔猪同时接触玉米赤霉烯酮（ZEN）和赭曲霉毒素A（OTA）的解毒效果。
总共60头28日龄仔猪被平均分配到四个实验组（A - D），每组由8头雌性和7头雄性仔猪组成（每组15只动物，试验总时长42天）。A组动物接受不含霉菌毒素或测试产品[多组分霉菌毒素解毒剂（MMDA）]的典型断奶仔猪饲料。B组动物接受含有0.992 mg ZEN/kg饲料和0.531 mg OTA/kg饲料的相同断奶仔猪饲料，不添加MMDA。C组动物接受与B组相同的污染饲料，并添加1.5 g MMDA/kg饲料，而D组动物接受与B组相同的饲料，并添加3 g MMDA/kg饲料。评估临床症状和生产性能参数[体重（BW）、平均日增重（ADWG）和饲料转化率（FCR）]，同时还评估肝脏和肾脏组织中的霉菌毒素残留。
结果显示，与接受较低剂量（1.5 g MMDA/kg饲料）的组相比，接受最大剂量测试产品（3 g MMDA/kg饲料）的组的FCR有所改善。一些血液学和生化参数略有改变，但主要在正常范围内。残留分析表明，与未添加测试产品而只接受毒素的组相比，接受最大MMDA剂量的组的肝脏样本中的OTA、肝脏和总测试样本中的α - ZEL以及所有样本中的ZEN及其代谢物总量均有所减少。
因此，建议在同时接触ZEN和OTA的情况下，最大剂量方案的MMDA对降低ZEN和OTA的生物利用度和组织沉积具有积极作用，对断奶仔猪的FCR具有特别积极的影响。
