Mental Illness Research Department, Valdecilla Biomedical Research Institute (IDIVAL), 39011, Santander, Spain.
Department of Medicine and Health Sciences, Faculty of Medicine, University of Cantabria (UC), 39011, Santander, Spain.
Arch Womens Ment Health. 2024 Oct;27(5):693-703. doi: 10.1007/s00737-024-01457-x. Epub 2024 Mar 21.
The study aimed to explore the role of parenthood at first episode of psychosis (FEP) on recovery, with a focus on potential sex differences.
Sociodemographic, clinical, and neurocognitive information was considered on 610 FEP patients form the PAFIP cohort (Spain). Baseline and three-year follow-up comparisons were carried out. Chi-square tests and ANCOVA analysis were performed controlling for the effect of age and years of education.
Men comprised 57.54% of the sample, with only 5.41% having offspring when compared to 36.29% of women. Parenthood was related to shorter duration of untreated illness (DUI) in women with children (12.08 months mothers vs. 27.61 months no mothers), showing mothers better premorbid adjustment as well. Childless men presented the worst premorbid adjustment and the highest cannabis and tobacco consumption rates. Mothers presented better global cognitive function, particularly in attention, motor dexterity and executive function at three-year follow-up.
Diminished parental rates among FEP men could be suggested as a consequence of a younger age of illness onset. Sex roles in caregiving may explain the potential role of parenthood on premorbid phase, with a better and heathier profile, and a more favorable long-term outcome in women. These characteristics may be relevant when adjusting treatment specific needs in men and women with and without offspring.
本研究旨在探讨首发精神病（FEP）患者的父母身份对康复的作用，重点关注潜在的性别差异。
对来自 PAFIP 队列（西班牙）的 610 名 FEP 患者的社会人口学、临床和神经认知信息进行了考虑。进行了基线和 3 年随访比较。进行了卡方检验和协方差分析，控制了年龄和受教育年限的影响。
男性占样本的 57.54%，与女性的 36.29%相比，仅有 5.41%的患者有子女。有子女的女性未治疗疾病持续时间（DUI）更短（母亲为 12.08 个月，无子女为 27.61 个月），表明母亲的病前调整更好。无子女的男性病前调整最差，大麻和烟草消费率最高。母亲在 3 年随访时表现出更好的整体认知功能，特别是在注意力、运动灵巧性和执行功能方面。
FEP 男性中父母比例较低可能是由于发病年龄较轻所致。在照顾方面的性别角色可以解释父母身份对病前阶段的潜在作用，女性具有更好、更健康的特征，以及更有利的长期预后。这些特征在调整有和无子女的男性和女性的特定治疗需求时可能是相关的。
