Yu Z, Chen D M, Huang J L
Department of Laboratory Medicine, Gene Diagnosis Research Center, Fujian Key Laboratory of Laboratory Medicine, the First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, China.
Zhonghua Gan Zang Bing Za Zhi. 2024 Feb 20;32(2):180-185. doi: 10.3760/cma.j.cn501113-20240117-00034.
Hepatocellular carcinoma (HCC) is the most common liver malignant tumor with complex pathogenesis and a poor prognosis. Metabolic reprogramming has been recognized as one of the important cancer markers, and the liver, as an important organ for lipid metabolism in the human body, plays an important role in the process of the occurrence and development of HCC. More and more evidence shows that long-chain non-coding RNA (lncRNA) can influence the lipid metabolism process by regulating key enzymes and transcription factors, as well as being involved in the occurrence and development of HCC. Therefore, explicating the mechanism of lncRNA in lipid metabolism reprogramming is conducive to providing new targets and strategies for the diagnosis and treatment and improving the prognosis of HCC patients. This article summarizes the latest research progress on the involvement of lncRNA in the reprogramming process of HCC lipid metabolism.
肝细胞癌（HCC）是最常见的肝脏恶性肿瘤，其发病机制复杂，预后较差。代谢重编程已被公认为重要的癌症标志物之一，而肝脏作为人体脂质代谢的重要器官，在HCC的发生发展过程中起着重要作用。越来越多的证据表明，长链非编码RNA（lncRNA）可通过调节关键酶和转录因子影响脂质代谢过程，且参与HCC的发生发展。因此，阐明lncRNA在脂质代谢重编程中的机制，有助于为HCC的诊断和治疗提供新的靶点和策略，改善HCC患者的预后。本文综述了lncRNA参与HCC脂质代谢重编程过程的最新研究进展。
