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职业人群不健康生活方式与糖尿病血脂异常的关联及网络分析

[Association between unhealthy lifestyles and diabetic dyslipidemia in occupational population and network analysis].

作者信息

Ma C L, Yu B, Fan Y Z, Ye T T, Cai C W, Yang B, Zeng H L, Jia P, Yang S J

机构信息

West China School of Public Health/The Fourth Hospital of West China, Sichuan University, Chengdu 610041, China.

West China School of Public Health/The Fourth Hospital of West China, Sichuan University, Chengdu 610041, China Institute for Disaster Management and Reconstruction, Sichuan University-the Hong Kong Polytechnic University, Chengdu 610207, China.

出版信息

Zhonghua Liu Xing Bing Xue Za Zhi. 2024 Mar 10;45(3):425-431. doi: 10.3760/cma.j.cn112338-20230715-00007.

Abstract

To understand the influence of unhealthy lifestyle on diabetic dyslipidemia and the key influencing factors in occupational population and provided scientific evidence for the prevention of diabetic dyslipidemia. Based on baseline data and follow-up data of Southwest Occupational Population Cohort from China Railway Chengdu Group Co., Ltd. during 2021. Diabetic dyslipidemia was defined as diabetes plus one or more forms of dyslipidemia, and unhealthy lifestyle factors included smoking, alcohol consumption, unhealthy dietary patterns, low physical activity, and abnormal BMI. Multivariate logistic regression model was used to analyze the relationship between unhealthy lifestyle scores and diabetic dyslipidemia, network analysis was used to find and explore the key lifestyles influencing glycolipid metabolism. A total of 25 631 subjects were included. People with unhealthy lifestyle score 2 and 3 were 1.93 (95%: 1.31-2.86) times and 2.37 (95%: 1.60-3.50) times more likely to have diabetes with ≥1 forms of dyslipidemia than those with scores of 0; People with unhealthy lifestyle score 1, 2 and 3 were 1.98 (95%: 1.08-3.61) times, 2.87 (95%: 1.60-5.14) times and 3.95 (95%: 2.22-7.06) times more likely to have diabetes with ≥2 forms of dyslipidemia than those with score 0. Network analysis found that abnormal BMI and HDL-C were the "bridge nodes" that link unhealthy lifestyles with diabetic dyslipidemia. The higher the score of unhealthy lifestyle, the higher the risk for diabetic dyslipidemia, abnormal BMI and HDL-C are key factors influencing the association between unhealthy lifestyle and diabetic dyslipidemia.

摘要

为了解不健康生活方式对糖尿病血脂异常的影响以及职业人群中的关键影响因素,为糖尿病血脂异常的预防提供科学依据。基于中国铁路成都局集团有限公司西南职业人群队列2021年的基线数据和随访数据。糖尿病血脂异常定义为糖尿病合并一种或多种血脂异常形式,不健康生活方式因素包括吸烟、饮酒、不健康饮食模式、低体力活动和BMI异常。采用多因素logistic回归模型分析不健康生活方式得分与糖尿病血脂异常的关系,采用网络分析寻找和探索影响糖脂代谢的关键生活方式。共纳入25631名受试者。不健康生活方式得分2和3的人群患有一种及以上血脂异常形式糖尿病的可能性分别是得分0人群的1.93倍(95%:1.31-2.86)和2.37倍(95%:1.60-3.50);不健康生活方式得分1、2和3的人群患有两种及以上血脂异常形式糖尿病的可能性分别是得分0人群的1.98倍(95%:1.08-3.61)、2.87倍(95%:1.60-5.14)和3.95倍(95%:2.22-7.06)。网络分析发现BMI异常和HDL-C是连接不健康生活方式与糖尿病血脂异常的“桥梁节点”。不健康生活方式得分越高,糖尿病血脂异常风险越高,BMI异常和HDL-C是影响不健康生活方式与糖尿病血脂异常关联的关键因素。

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