Department of Gastroenterology, Renmin Hospital of Wuhan University, 99 Zhangzhidong Road, Wuhan, 430060, China.
Sleep Breath. 2024 Jun;28(3):1381-1391. doi: 10.1007/s11325-024-03017-0. Epub 2024 Mar 22.
The relationships of sleep factors separately and jointly with metabolic associated fatty liver disease (MAFLD) and significant fibrosis remain unclear. We intended to explore the relationships in the United States.
This cross-sectional study included 4477 individuals from the National Health and Nutrition Examination Survey from 2017 to 2018. Information regarding each sleep factor (sleep duration, trouble sleeping, snoring, excessive daytime sleep, and sleep apnea symptoms) was obtained through questionnaires. MAFLD was diagnosed by transient elastography according to the consensus definitions. Multivariable logistic regression models were employed to explore relationships of sleep factors separately and jointly with MAFLD and significant fibrosis.
Participants having a poor sleep pattern was associated with higher MAFLD and significant fibrosis risk, and poor sleep pattern was related to about threefold (OR, 3.67; 95% CI, 1.82-7.37) increased risk of MAFLD remarkably. When examining specific factors of sleep patterns individually, trouble sleeping (OR, 1.53; 95% CI, 1.10-2.12), snoring (OR, 2.11; 95% CI, 1.40-3.19), excessive daytime sleep (OR, 1.57; 95% CI, 0.93-2.62), and sleep apnea symptoms (OR, 1.87; 95% CI, 1.13-3.10) were positively associated with the odds of MAFLD (all P < 0.05). However, sleep duration was not independently correlated with MAFLD or significant fibrosis. Sleep patterns showed similar relationships with MAFLD, regardless of all age, sex, physical activity, and shift work groups.
Poor sleep pattern was linked with a considerably higher risk of MAFLD and significant fibrosis.
睡眠因素与代谢相关脂肪性肝病（MAFLD）和显著纤维化的关系单独和联合仍不清楚。我们旨在探讨美国的这些关系。
本横断面研究纳入了 2017 年至 2018 年国家健康和营养调查中的 4477 名个体。通过问卷获得了关于每个睡眠因素（睡眠时间、睡眠障碍、打鼾、白天过度嗜睡和睡眠呼吸暂停症状）的信息。根据共识定义，通过瞬时弹性成像诊断 MAFLD。采用多变量逻辑回归模型探讨睡眠因素单独和联合与 MAFLD 和显著纤维化的关系。
睡眠模式差与 MAFLD 和显著纤维化风险增加有关，且睡眠模式差与 MAFLD 风险显著增加近三倍（OR，3.67；95%CI，1.82-7.37）。当单独检查睡眠模式的特定因素时，睡眠障碍（OR，1.53；95%CI，1.10-2.12）、打鼾（OR，2.11；95%CI，1.40-3.19）、白天过度嗜睡（OR，1.57；95%CI，0.93-2.62）和睡眠呼吸暂停症状（OR，1.87；95%CI，1.13-3.10）与 MAFLD 的发生几率呈正相关（均 P<0.05）。然而，睡眠时间与 MAFLD 或显著纤维化无关。无论年龄、性别、体力活动和轮班工作组别如何，睡眠模式与 MAFLD 均显示出相似的关系。
睡眠模式差与 MAFLD 和显著纤维化的风险显著增加有关。
