Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China.
Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China.
Clin Res Hepatol Gastroenterol. 2024 Apr;48(4):102320. doi: 10.1016/j.clinre.2024.102320. Epub 2024 Mar 12.
The independent and joint association of physical activity (PA) and weekday sleep duration with metabolic dysfunction-associated steatotic liver disease (MASLD) remain unclear.
We intended to explore this association in the United States.
This cross-sectional study recruited 4974 individuals from the National Health and Nutrition Examination Survey between 2017 and 2018. Information regarding PA and weekday sleep duration was obtained through questionnaires. Metabolic associated fatty liver disease (MAFLD) was diagnosed by transient elastography based on the consensus definitions. Multivariable logistic regression models were employed to investigate the independent and joint association of PA and weekday sleep duration with MAFLD.
Of the 4974 subjects, engaging in active PA or sustaining adequate sleep duration was associated with decreased the odds of MAFLD (p < 0.05). Specifically, active leisure-time PA was linked to lower 37 % odds of MAFLD (OR, 0.63; 95 % CI, 0.55-0.73). Individuals who had one to twice times (150-299 min/week) or more than twice (≥300 min/week) the recommended amount of leisure-time PA by PA Guidelines had 19 % (OR, 0.81; 95 % CI, 0.67-0.99) and 45 % (OR, 0.55; 95 % CI, 0.47-0.65) lower odds of MAFLD, respectively (P for trend <0.001). Individuals with adequate weekday sleep duration was associated with 24 % lower odds of MAFLD (OR, 0.76;95 % CI,0.67-0.88). Notably, active PA combined with adequate weekday sleep duration significantly decreased the odds ratios for MAFLD by 35 % (OR: 0.65, 95 % CI, 0.52-0.80). However, in individuals with significant alcohol use, the joint effect of total PA and weekday sleep duration on MAFLD was not statistically significant.
Both active PA and adequate weekday sleep duration were inversely associated with the risk of MASLD independently, while combining them could further lower the risk of MASLD.
体力活动（PA）和工作日睡眠时长与代谢相关脂肪性肝病（MASLD）的独立和联合关联仍不清楚。
我们旨在探讨这种关联在美国人群中的情况。
本横断面研究于 2017 年至 2018 年期间招募了来自全国健康和营养检查调查（NHANES）的 4974 名个体。通过问卷调查获取关于 PA 和工作日睡眠时长的信息。使用瞬时弹性成像技术基于共识定义诊断代谢相关脂肪性肝疾病（MAFLD）。采用多变量逻辑回归模型探讨 PA 和工作日睡眠时长与 MAFLD 的独立和联合关联。
在 4974 名受试者中，进行积极的 PA 或保持足够的睡眠时长与 MAFLD 的几率降低有关（p<0.05）。具体而言，积极的休闲时间 PA 与 MAFLD 的几率降低 37%相关（OR，0.63；95%CI，0.55-0.73）。根据 PA 指南，每周进行一次到两次（150-299 分钟/周）或两次以上（≥300 分钟/周）推荐量的休闲时间 PA 的个体 MAFLD 的几率分别降低 19%（OR，0.81；95%CI，0.67-0.99）和 45%（OR，0.55；95%CI，0.47-0.65）（P 趋势<0.001）。工作日睡眠充足的个体 MAFLD 的几率降低 24%（OR，0.76；95%CI，0.67-0.88）。值得注意的是，积极的 PA 结合充足的工作日睡眠时长可使 MAFLD 的比值比降低 35%（OR：0.65，95%CI，0.52-0.80）。然而，在大量饮酒的个体中，PA 总量和工作日睡眠时长对 MAFLD 的联合作用无统计学意义。
积极的 PA 和足够的工作日睡眠时长均与 MASLD 的风险呈负相关，独立相关，而两者结合可进一步降低 MASLD 的风险。
