Hao Chenguang, Chen Shibao
The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Bayingolin Mongolian Autonomous Prefecture People's Hospital, Korla, China.
Adv Clin Exp Med. 2025 Feb;34(2):153-163. doi: 10.17219/acem/184641.
Acute ischemic stroke (AIS) has a high rate of death and causes long-term disability, leading to a global economic burden annually. Therefore, discovering biomarkers to improve AIS patient prognosis is critical. Previous studies reported an association between serum cystatin C (CysC) levels and outcomes in AIS patients, but the results remain controversial. This systematic review and meta-analysis aimed to explore the relationship between serum CysC and AIS patient outcomes using currently available studies. The literature search included PubMed, Embase, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI), VIP, and Wan Fang databases. Outcomes included poor functional recovery, cognitive dysfunction and death. Weighted mean difference (WMD) with 95% confidence interval (95% CI) was used as an effect index for measurement data. Results demonstrated that serum CysC was significantly higher in AIS patients with poor functional recovery (WMD = 0.18, 95% CI: 0.08-0.28), cognitive dysfunction (WMD = 0.16, 95% CI: 0.09-0.23) and death (WMD = 0.32, 95% CI: 0.02-0.62) than in the control groups when follow-up time was <1 month. These findings show that high serum CysC levels were associated with poor AIS patient outcomes. Further studies are needed to examine whether reducing serum CysC can prevent poor outcomes in AIS patients.
急性缺血性卒中（AIS）死亡率高，并会导致长期残疾，每年造成全球经济负担。因此，发现生物标志物以改善AIS患者的预后至关重要。先前的研究报道了血清胱抑素C（CysC）水平与AIS患者预后之间的关联，但结果仍存在争议。本系统评价和荟萃分析旨在利用现有研究探讨血清CysC与AIS患者预后之间的关系。文献检索包括PubMed、Embase、Web of Science、Cochrane图书馆、中国知网（CNKI）、维普资讯（VIP）和万方数据库。结局包括功能恢复差、认知功能障碍和死亡。加权均数差（WMD）及其95%置信区间（95%CI）用作计量资料的效应指标。结果表明，随访时间<1个月时，功能恢复差的AIS患者（WMD = 0.18，95%CI：0.08 - 0.28）、认知功能障碍患者（WMD = 0.16，95%CI：0.09 - 0.23）和死亡患者（WMD = 0.32，95%CI：0.02 - 0.62）的血清CysC水平显著高于对照组。这些发现表明，血清CysC水平升高与AIS患者预后不良有关。需要进一步研究以检验降低血清CysC水平是否可以预防AIS患者的不良结局。
