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情绪障碍中的精氨酸代谢组学

Arginine metabolomics in mood disorders.

作者信息

Zinellu Angelo, Tommasi Sara, Sedda Stefania, Mangoni Arduino A

机构信息

Department of Biomedical Sciences, University of Sassari, Sassari, Italy.

Department of Clinical Pharmacology, Southern Adelaide Local Health Network, Australia.

出版信息

Heliyon. 2024 Mar 14;10(6):e27292. doi: 10.1016/j.heliyon.2024.e27292. eCollection 2024 Mar 30.

DOI:10.1016/j.heliyon.2024.e27292
PMID:38515671
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10955251/
Abstract

Alterations of nitric oxide (NO) homeostasis have been described in mood disorders. However, the analytical challenges associated with the direct measurement of NO have prompted the search for alternative biomarkers of NO synthesis. We investigated the published evidence of the association between these alternative biomarkers and mood disorders (depressive disorder or bipolar disorder). Electronic databases were searched from inception to the June 30, 2023. In 20 studies, there was a trend towards significantly higher asymmetric dimethylarginine (ADMA) in mood disorders vs. controls (p = 0.072), and non-significant differences in arginine (p = 0.29), citrulline (p = 0.35), symmetric dimethylarginine (SDMA; p = 0.23), and ornithine (p = 0.42). In subgroup analyses, the SMD for ADMA was significant in bipolar disorder (p < 0.001) and European studies (p = 0.02), the SMDs for SDMA (p = 0.001) and citrulline (p = 0.038) in European studies, and the SMD for ornithine in bipolar disorder (p = 0.007), Asian (p = 0.001) and American studies (p = 0.005), and patients treated with antidepressants (p = 0.029). The abnormal concentrations of ADMA, SDMA, citrulline, and ornithine in subgroups of mood disorders, particularly bipolar disorder, warrant further research to unravel their pathophysiological role and identify novel treatments in this group (The protocol was registered in PROSPERO: CRD42023445962).

摘要

一氧化氮（NO）稳态的改变已在情绪障碍中有所描述。然而，与直接测量NO相关的分析挑战促使人们寻找NO合成的替代生物标志物。我们调查了这些替代生物标志物与情绪障碍（抑郁症或双相情感障碍）之间关联的已发表证据。从数据库创建到2023年6月30日进行了电子数据库搜索。在20项研究中，情绪障碍患者与对照组相比，不对称二甲基精氨酸（ADMA）有显著升高的趋势（p = 0.072），而精氨酸（p = 0.29）、瓜氨酸（p = 0.35）、对称二甲基精氨酸（SDMA；p = 0.23）和鸟氨酸（p = 0.42）无显著差异。在亚组分析中，ADMA的标准化均数差在双相情感障碍（p < 0.001）和欧洲研究（p = 0.02）中显著，SDMA（p = 0.001）和瓜氨酸（p = 0.038）的标准化均数差在欧洲研究中显著，鸟氨酸的标准化均数差在双相情感障碍（p = 0.007）、亚洲（p = 0.001）和美国研究（p = 0.005）以及接受抗抑郁药治疗的患者（p = 0.029）中显著。情绪障碍亚组，尤其是双相情感障碍中ADMA、SDMA、瓜氨酸和鸟氨酸的异常浓度，值得进一步研究以阐明其病理生理作用并确定该组的新治疗方法（该方案已在国际前瞻性系统评价注册库PROSPERO中注册：CRD42023445962）。

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