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[植物名称]的叶提取物可促进[动物名称]的抗热应激和抗氧化作用。

Leaf extract of promotes anti-heat stress and antioxidant effects in .

作者信息

Chuaijit Sirithip, Punsawad Chuchard, Winoto Veronica, Plaingam Waluga, Kongkaew Itti, Phetcharat Atidtaya, Ichikawa Takafumi, Kubo Makoto, Kawakami Fumitaka, Tedasen Aman, Chatatikun Moragot

机构信息

Department of Medical Science, School of Medicine, Walailak University, Nakhon Si Thammarat, Thailand.

Research Center in Tropical Pathobiology, Walailak University, Nakhon Si Thammarat, Thailand.

出版信息

Front Pharmacol. 2024 Mar 7;15:1331627. doi: 10.3389/fphar.2024.1331627. eCollection 2024.

DOI:10.3389/fphar.2024.1331627
PMID:38515852
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10955098/
Abstract

has been used for traditional medicines, healthy foods and tea. The chemical compositions and biological activities of fruit, stem bark and root have been widely studied. However, the phytochemical components and the biological activities in leaves (GAL) are limited. This research aims to study the phytochemical components and the stress resistance effects of GAL in (). To investigate the chemical components and antioxidant activities of GAL extract, the ethanol extract was characterized by liquid chromatography-quadrupole time-of-flight mass spectrometry (LC-QTOF MS) analysis and was used to evaluate the effects of GAL extracts on longevity and stress resistance. The results revealed that the ethanol extract of GAL possesses free radical scavenging activities. Furthermore, GAL extract increased the lifespan of by 6.02%, 15.26%, and 12.75% at concentrations of 25, 50, and 100 μg/mL, respectively. GAL extract exhibited improved stress resistance under conditions of heat and hydrogen peroxide-induced stress. The survival rates of GAL extract-treated worms were significantly higher than those of untreated worms, and GAL extract reduced reactive oxygen species (ROS) accumulation. Additionally, GAL extract treatment upregulated the expression of stress resistance-associated genes, including gst-4, sod-3, skn-1, and hsp16.2. GAL extract supplementation alleviated stress and enhanced longevity by inducing stress-related genes in . The observed effects of GAL extracts may be attributed to the stimulation of oxidant enzymes mediated through DAF-16/FOXO and SKN-1/NRF2, as well as the enhancement of thermal defense in . Collectively, this study provides the first evidence of the antioxidant activities of GAL and elucidates the underlying mechanisms of stress resistance.

摘要

已被用于传统药物、健康食品和茶中。果实、茎皮和根的化学成分及生物活性已得到广泛研究。然而，叶片（GAL）中的植物化学成分和生物活性研究有限。本研究旨在研究GAL在（）中的植物化学成分及抗逆作用。为研究GAL提取物的化学成分和抗氧化活性，采用液相色谱 - 四极杆飞行时间质谱（LC - QTOF MS）分析对乙醇提取物进行表征，并用于评估GAL提取物对寿命和抗逆性的影响。结果表明，GAL乙醇提取物具有自由基清除活性。此外，GAL提取物在浓度为25、50和100μg/mL时，分别使（）的寿命延长了6.02%、15.26%和12.75%。在热和过氧化氢诱导的应激条件下，GAL提取物表现出增强的抗逆性。经GAL提取物处理的线虫存活率显著高于未处理的线虫，且GAL提取物减少了活性氧（ROS）积累。此外，GAL提取物处理上调了包括gst - 4、sod - 3、skn - 1和hsp16.2在内的抗逆相关基因的表达。补充GAL提取物通过诱导（）中的应激相关基因减轻了应激并延长了寿命。GAL提取物观察到的效果可能归因于通过DAF - 16/FOXO和SKN - 1/NRF2介导的氧化酶刺激，以及（）中热防御的增强。总体而言，本研究提供了GAL抗氧化活性的首个证据，并阐明了抗逆的潜在机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdab/10955098/09ef78a65106/fphar-15-1331627-g007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdab/10955098/09ef78a65106/fphar-15-1331627-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdab/10955098/b774044bcff8/fphar-15-1331627-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdab/10955098/5bbb5d409e65/fphar-15-1331627-g002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdab/10955098/09ef78a65106/fphar-15-1331627-g007.jpg

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