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宫颈腺癌合并神经内分泌癌:一例报告及文献复习

Adenocarcinoma admixed with neuroendocrine carcinoma of the cervix: A case report and review of literature.

作者信息

Molla Yohannis Derbew, Alemu Hirut Tesfahun, Selamawi Almaz Enku, Tesema Amare Yeshitla, Answar Isak Omer, Tadesse Amanuel Kassa

机构信息

Department of Surgery, College of Medicine and Health Sciences, University of Gondar, 196 Gondar, Ethiopia.

College of Medicine and Health Sciences, University of Gondar, 196 Gondar, Ethiopia.

出版信息

Case Rep Womens Health. 2024 Mar 12;41:e00594. doi: 10.1016/j.crwh.2024.e00594. eCollection 2024 Mar.

Abstract

A 40-year-old Ethiopian woman presented with a six-month history of non-foul-smelling whitish vaginal discharge. She also reported a one-year history of postcoital bleeding. A pelvic examination revealed a nodular, hard, and fragile cervical mass. In addition, there were nontender, firm nodules in the epigastric, periumbilical, gluteal areas, and thyroid gland. Investigations, including abdominopelvic ultrasound, magnetic resonance imaging, fine-needle aspiration cytology, and immunohistochemistry, confirmed mixed neuroendocrine carcinoma of the cervix with metastasis to the abdominal wall, gluteal area, lumbar vertebrae, and thyroid gland. The patient was started on palliative chemotherapy. Metastatic adenocarcinoma admixed with neuroendocrine carcinoma of the cervix presents a formidable disease phenotype, characterized by complex diagnostic and therapeutic obstacles. Multidisciplinary cooperation among oncologists, radiologists, pathologists, and surgeons is required to refine treatment approaches and improve patient prognoses for this uncommon and intricate malignancy.

摘要

一名40岁的埃塞俄比亚女性出现了六个月的无异味白色阴道分泌物病史。她还报告有一年的性交后出血病史。盆腔检查发现宫颈有一个结节状、坚硬且脆弱的肿块。此外,在上腹部、脐周、臀部区域和甲状腺有不压痛的坚实结节。包括腹盆腔超声、磁共振成像、细针穿刺细胞学检查和免疫组织化学在内的检查证实为宫颈混合性神经内分泌癌,已转移至腹壁、臀部区域、腰椎和甲状腺。患者开始接受姑息化疗。宫颈转移性腺癌合并神经内分泌癌呈现出一种可怕的疾病表型,其特点是存在复杂的诊断和治疗障碍。肿瘤学家、放射科医生、病理学家和外科医生之间需要多学科合作,以完善治疗方法并改善这种罕见且复杂恶性肿瘤患者的预后。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95e1/10955200/e0598f2098b7/gr1.jpg

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