Tatlı Safiye Zeynep, Araz Mine, Özkan Elgin, Peker Elif, Erden Mehmetİlhan, Cankorur VesileŞentürk
Faculty of Medicine, Ankara University, Ankara, Türkiye.
Front Psychiatry. 2024 Mar 7;15:1336881. doi: 10.3389/fpsyt.2024.1336881. eCollection 2024.
Several neuroimaging studies have been conducted to demonstrate the specific structural and functional brain correlations of conversion disorder. Although the findings of neuroimaging studies are not consistent, when evaluated as a whole, they suggest the presence of significant brain abnormalities. The aim of this study is to investigate brain metabolic activity through F-18 fluorodeoxyglucose PET/MRI in order to shed light on the neural correlates of conversion disorder.
20 patients diagnosed with conversion disorder were included in the study. Hamilton Depression and Anxiety Rating Scales, Somatosensory Amplification Scale and Somatoform Dissociation Scale were administered. Then, brain F-18 FDG-PET/MRI was performed..
Hypermetabolism was found in posterior cingulate R, while glucose metabolisms of other brain regions were observed to be within the normal limits. When compared with the control group, statistically significant differences in z-scores were observed among all brain regions except for parietal superior R and cerebellum. No correlation was observed between the metabolisms of the left ACC and left medial PFC; left ACC and left temporal lateral cortex; cerebellum and left parietal inferior cortex despite the presence of positive correlations between these regions in the opposite hemisphere.
Results of the study suggest a potential involvement of the DMN which is associated with arousal and self-referential processing as well as regions associated with motor intention and self-agency.
已经进行了多项神经影像学研究，以证明转换障碍的特定脑结构和功能相关性。尽管神经影像学研究的结果并不一致，但总体评估时，它们表明存在明显的脑异常。本研究的目的是通过F-18氟脱氧葡萄糖PET/MRI来研究脑代谢活动，以阐明转换障碍的神经相关性。
20名被诊断为转换障碍的患者纳入本研究。使用汉密尔顿抑郁和焦虑评定量表、体感放大量表和躯体形式解离量表进行评估。然后，进行脑部F-18 FDG-PET/MRI检查。
右侧后扣带回发现代谢亢进，而其他脑区的葡萄糖代谢在正常范围内。与对照组相比，除右侧顶上叶和小脑外，所有脑区的z分数均存在统计学显著差异。尽管在对侧半球这些区域之间存在正相关，但左侧前扣带回与左侧内侧前额叶皮质、左侧前扣带回与左侧颞外侧皮质、小脑与左侧顶下皮质之间的代谢未观察到相关性。
研究结果表明，与觉醒和自我参照加工相关的默认模式网络以及与运动意图和自我能动性相关的区域可能参与其中。
